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IFNG — KIR2DL4

Text-mined interactions from Literome

Rajagopalan et al., J Immunol 2001 : The induction by KIR2DL4 of IFN-gamma production by resting NK cells was blocked by an inhibitor of the p38 mitogen activated protein kinase signaling pathway, in contrast to the IL-2 induced IFN-gamma secretion that was sensitive to inhibition of the extracellular signal regulated kinase mitogen activated protein kinase pathway
Kikuchi-Maki et al., J Immunol 2005 : KIR2DL4 ( 2DL4, CD158d ), a member of the human killer cell Ig-like receptor (KIR) family, triggers potent IFN-gamma responses but weak cytotoxicity in resting NK cells
Goodridge et al., Mol Hum Reprod 2009 : In this study, we assessed KIR2DL4 expression and IFNgamma secretion as a result of KIR2DL4 ligation, by decidual NK ( dNK ) cells ... Although freshly isolated dNK did not secrete IFNgamma in response to KIR2DL4 ligation regardless of KIR2DL4 genotype, activation by in vitro culture with IL-2 enabled dNK cells from individuals with at least one 10A allele, but not those without a 10A allele, to secrete IFNgamma in response to KIR2DL4 ligation