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CDKN1B — E2F1

Pathways - manually collected, often from reviews:

• NCI Pathway Database E2F transcription factor network: E2F1/DP complex (E2F1-TFDP2_TFDP1) → p27Kip1 (CDKN1B) (transcription, activates) Wang et al., J Biol Chem 2005*, Wang et al., J Biol Chem 2007
  Evidence: mutant phenotype, reporter gene, physical interaction
• Reactome Reaction: E2F1 → CDKN1B (reaction) Connell-Crowley et al., Mol Biol Cell 1997

Text-mined interactions from Literome

Wang et al., J Biol Chem 2005 : Activation of p27Kip1 Expression by E2F1
Gysin et al., Cancer Res 2005 (MAP Kinase Signaling System...) : Inhibition of p27Kip1 expression in Mia PaCa-2 cells restored the activity of cyclin/cdk2, phosphorylation of pRb, and E2F activity and partially relieved the effects of U0126 on pancreatic cancer cell cycle arrest
Ozono et al., Genes Cells 2009 : The cyclin dependent kinase inhibitor p27 ( Kip1 ) gene, an upstream negative regulator of E2F, is induced by ectopically expressed E2F1 but not by normal growth stimulation that physiologically activates endogenous E2F
Shiyanov et al., Mol Biol Cell 1997 : The reduction in the expression of these genes correlates with the p27Kip1 induced accumulation of the repressor complexes of the E2F family of factors ( E2Fs )