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ADORA3 — EPHB2
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Schulte et al., Mol Pharmacol 2002
:
Furthermore the ERK1/2 phosphorylation was sensitive to the PI3K inhibitors wortmannin and LY294002 ( 2- ( 4-morpholinyl ) -8-phenyl-1 ( 4H ) -benzopyran-4-one hydrochloride ) and the MEK inhibitor PD98059 ( 2'-amino-3'-methoxyflavone ), whereas chelation of Ca ( 2+ ) with 1,2-bis ( 2-aminophenoxy ) ethane-N, N,N ', N'-tetraacetic acid tetrakis ( acetoxymethyl ester ) and long-term treatment with phorboldibutyrate did not decrease the
adenosine A(3) receptor mediated
ERK1/2 phosphorylation
Schulte et al., Exp Cell Res 2003
:
Thus, stimulation of
adenosine A ( 2B ) receptors
activates both
ERK1/2 and p38 via cAMP, but the downstream pathways are markedly different
Hammarberg et al., Biochem Pharmacol 2004
:
Furthermore, we identified the serine 727 site of signal transducer and activator of transcription STAT3 as a probable downstream target of ERK1/2, and thereby provide evidence that
adenosine A(3) receptor mediated
ERK1/2 activation has functional consequences
Button et al., Exp Physiol 2005
:
Phosphatidylinositol 3-kinase and
ERK1/2 are not
involved in
adenosine A1 , A2A or A3 receptor mediated preconditioning in rat ventricle strips
Nakata et al., Biochem Biophys Res Commun 2007
:
These neurite outgrowth and
ERK1/2 activation were significantly
inhibited by PD98059, an inhibitor of mitogen activated protein kinase kinase, as well as by activation of endogenous
adenosine A2A receptors