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EPHB2 — FGFR2
Text-mined interactions from Literome
Gaubert et al., J Biol Chem 2001
:
The expression of a dominant negative FGFR1 did not reduce ERK-1/2 activation by the HMW FGF-2, suggesting that
ERK activation does not
require FGFR activity
Cailliau et al., Biochim Biophys Acta 2001
:
In contrast,
FGFR4 stimulation by FGF2
induced an early transient activation of
ERK2 and no meiosis reinitiation
Kontaridis et al., Mol Cell Biol 2002
:
We propose that SHP-2
plays a pivotal role in
FGFR signaling in myoblasts via both
Erk dependent and Erk independent pathways
Gamady et al., J Cell Biochem 2003
:
Inhibition of protein kinase C with bisindolylmaleimide did not interfere with the effect of 1,25 ( OH ) ( 2 ) D ( 3 ) on
KGFR mediated
ERK activation
Li et al., J Cell Sci 2004
:
FRS2 dependent SRC activation is required for
fibroblast growth factor receptor induced phosphorylation of Sprouty and suppression of
ERK activity
Kuslak et al., Development 2007
:
This defect appears to be the immediate downstream effect of partial loss of FGFR2 ( IIIb ) because activation of
FGFR2 ( IIIb ) by FGF10 rapidly
induced ERK1/2 activation, and inhibition of ERK1/2 activation blocked seminal vesicle branching morphogenesis
Lao et al., J Biol Chem 2007
:
Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for
ERK inhibition downstream of
fibroblast growth factor receptor stimulation
Vincent et al., Osteoarthritis Cartilage 2007
(Mechanotransduction, Cellular) :
The loading response was assessed by the activation of
ERK , in the
presence or absence of a specific
FGFR inhibitor
Poliakov et al., J Cell Biol 2008
(MAP Kinase Signaling System) :
In addition,
FGFR1 signaling
inhibits further phosphorylation of
EphB2 upon stimulation with ephrinB1, and we show that this involves a requirement for the mitogen activated protein kinase ( MAPK ) pathway
Toriseva et al., PloS one 2012
(Carcinoma, Squamous Cell...) :
Activation of
ERK1/2 in HaCaT cells and tumorigenic Ha-ras transformed HaCaT cells
resulted in downregulation of MMP-13 and
KGFR expression
Ono et al., Hum Mol Genet 2013
:
The Ras-GTPase activity of neurofibromin restrains
ERK dependent
FGFR signaling during endochondral bone formation ... We provide here evidence that neurofibromin, via its Ras guanosine triphosphatase -activating activity, controls
ERK1/2 dependent fibroblast growth factor receptor (
FGFR ) signaling in chondrocytes