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ELN — MMP12

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: MMP12 — ELN (cleavage reaction, protease assay) Heinz et al., FEBS J 2010*
• IRef Matrixdb Interaction: ELN — MMP12 (direct interaction, enzymatic study) Taddese et al., Matrix Biol 2008*

Text-mined interactions from Literome

Ellerbroek et al., Arch Biochem Biophys 2001 (Autolysis) : However, MMP-2 is stabilized from autolysis in the presence of type I collagen, but not by elastin , fibrinogen, or laminin
Basalyga et al., Circulation 2004 (Aortic Diseases...) : Collectively, these data strongly indicate a correlation between MMP mediated elastin degradation and vascular calcification
Pellicoro et al., Hepatology 2012 (Liver Cirrhosis, Experimental) : Macrophage derived MMP-12 regulates elastin degradation even in progressive experimental liver fibrosis
Almine et al., FASEB J 2013 : Tropoelastin triggered fibroblast expression of the metalloelastase MMP-12 , which is normally expressed by macrophages
Chapman et al., Biochem J 1984 : Additional experiments indicated that the plasmin enhancement was due to elastin dependent activation of latent macrophage elastase