Lingohr et al., Mol Cell Endocrinol 2003
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In contrast, glucose/IGF-1 induced Erk-1/-2 and p70S6K activation were unaffected by IRS-3 Hügl et al., J Biol Chem 1998
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Thus, glucose and IGF-I induced beta-cell proliferation were mediated via a signaling mechanism that was facilitated by mitogen activated protein kinase but dependent on IRS mediated induction of PI 3'-kinase activity and downstream activation of p70 ( S6K )