Adam et al., Endocrinology 1999
(Prostatic Neoplasms) :
Expression of both ARG and HB-EGF mRNAs was induced in cultured prostate SMC by fibroblast growth factor-2 , a human prostate SMC mitogen linked to prostate disease
Peifley et al., Circ Res 1996
:
In the present study, we report that HB-EGF treatment of serum starved at aortic SMCs can induce fibroblast growth factor (FGF)-2 ( basic FGF ) gene expression but not FGF-1 ( acidic FGF ) gene expression ... The effect of HB-EGF on FGF-2 mRNA levels appears to be mediated primarily by a transcriptional mechanism and requires de novo synthesized proteins ... HB-EGF induction of FGF-2 mRNA levels can be inhibited by treating cells with the anti-inflammatory glucocorticoid dexamethasone or the glycosaminoglycan heparin
Mishima et al., Acta Neuropathol 1998
(Glioblastoma...) :
When added to the medium, transforming growth factor-alpha, basic fibroblast growth factor , or HB-EGF rapidly induced HB-EGF mRNA expression