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FGF2 — PRG3

Text-mined interactions from Literome

Bodo et al., Eur J Cell Biol 1999 (Craniofacial Dysostosis) : Since coactivation of interleukins and basic fibroblast growth factor (bFGF) is probably implicated in morphogenetic and osteogenic processes and heparan sulphate proteoglycans have a critical role in regulating bFGF activity, the phenotypes of normal and Crouzon osteoblasts were studied and the effects of bFGF on the expression of bFGF, procollagen alpha1 ( I ), and proteoglycan ( PG ) genes for biglycan, decorin, betaglycan and syndecan analyzed
Jayson et al., Int J Cancer 1999 (Adenoma...) : These findings were associated with a reduced biological response to bFGF in the carcinoma cells that could be partially reversed by the addition of exogenous heparin, suggesting that both the proteoglycan and signal transducing receptor control the cells ' response to bFGF
Shimazu et al., J Periodontal Res 2003 : bFGF increased [ 3H ] thymidine incorporation and suppressed proteoglycan synthesis concentration-dependently
Nugent et al., J Biol Chem 1992 : The possibility that TGF-beta 1 synergistically regulates bFGF activity by altering bFGF-proteoglycan interactions was investigated
Jenniskens et al., Osteoarthritis Cartilage 2006 : Examine effects of insulin-like growth factor 1 (IGF1), transforming growth factor beta2 ( TGFbeta2 ) and fibroblast growth factor 2 (FGF2) on proteoglycan and collagen network and biomechanical properties of the newly formed cartilage matrix
Shimabukuro et al., Matrix Biol 2008 : We examined the effects of basic fibroblast growth factor-2 ( FGF-2 ), which is known to modulate extracellular matrix ( ECM ) production of various cell types, on the production of HS proteoglycan by human periodontal ligament (HPDL) cells ... Taken together, FGF-2 may differentially regulate the expression of HS proteoglycans in a HS-proteoglycan-subtype dependent manner ... Taken together, FGF-2 may differentially regulate the expression of HS proteoglycans in a HS-proteoglycan-subtype dependent manner
Clark et al., J Invest Dermatol 2008 : ECM and pericellular matrix molecules were first recognized to complex with GFs and regulate GF activity by the seminal observations that basic fibroblast growth factor ( bFGF or FGF-2 ) required binding to a cell-surface heparin sulfate proteoglycan and to its authentic cell-surface receptor for biological activity ( Klagsbrun and Baird, 1991 ; Yayon et al., 1991 )
Sawaji et al., Arthritis Rheum 2008 : FGF-2 did not prevent IL-1alpha suppression of proteoglycan synthesis and did not negate its ability to stimulate the production of IL-6, IL-8, and MMPs 1, 3, and 13
Demarquay et al., Horm Res 1990 : bFGF mostly stimulates chondrocyte DNA and inhibits sulfated proteoglycan synthesis and type II collagen mRNA
Sachs et al., J Cell Physiol 1982 : The growth promoting activity of pituitary fibroblast growth factor ( FGF ) and its effect on sulfated-proteoglycan synthesis was studied on each chondrocyte population in secondary monolayer culture
Berrou et al., Biochem J 1995 : While bFGF and/or TGF-beta 1 enhanced cell-surface proteoglycan synthesis, 35S labelled proteoglycans of the extracellular matrix ( ECM ) were not affected
Rosselot et al., J Bone Miner Res 1994 : Effect of growth hormone, insulin-like growth factor I, basic fibroblast growth factor , and transforming growth factor beta on cell proliferation and proteoglycan synthesis by avian postembryonic growth plate chondrocytes
Okazaki et al., Ann Rheum Dis 1996 : To clarify the effects of transforming growth factor beta 1 ( TGF beta 1 ), TGF beta 2, and basic fibroblast growth factor (bFGF) on cell proliferation and proteoglycan ( PG ) synthesis in articular chondrocytes obtained from immobilised rabbit knees
Nakazawa et al., J Biochem 1996 : bFGF and TGF-beta 1 increased proteoglycan synthesis as a whole to some extent, but chondroitin sulfate/dermatan sulfate synthesis was increased preferentially and, consequently, the proportion of keratan sulfate synthesis to total synthesis was decreased
Filla et al., J Cell Physiol 1998 (Burkitt Lymphoma) : The cell surface proteoglycan syndecan-1 mediates fibroblast growth factor-2 binding and activity
Caldwell et al., Exp Neurol 1998 : There is increasing evidence that the proteoglycan heparin plays a critical role in the regulation of the activity of FGF-2 by either interacting with its receptor or modifying its stability and functioning