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GRB2 — IRS4

Pathways - manually collected, often from reviews:

• KEGG Insulin signaling pathway: IRS1/IRS2/IRS4 → GRB2 (protein-protein, activation)
• WikiPathways Insulin Signaling: SHC3/IRS1/IRS2/SHC1/IRS4/SHC2/GAB1 → RAC1/GRB2/SOS1/RAC2/RRAD/GRB14/SOS2/RAF1/HRAS/GRB10 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: IRS4 — GRB2 (coimmunoprecipitation) Qiu et al., Oncogene 2005*
• IRef Biogrid Interaction: IRS4 — GRB2 (physical association, affinity chromatography technology) Bisson et al., Nat Biotechnol 2011
• IRef Biogrid Interaction: IRS4 — GRB2 (physical association, affinity chromatography technology) Fantin et al., J Biol Chem 1998
• IRef Hprd Interaction: IRS4 — GRB2 (in vivo) Fantin et al., J Biol Chem 1998
• IRef Innatedb Interaction: GRB2 — IRS4 (unknown, -) Hinsby et al., J Biol Chem 2004*
• IRef Ophid Interaction: GRB2 — IRS4 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005