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CCR7 — TNF
Text-mined interactions from Literome
Vecchi et al., J Leukoc Biol 1999
:
TNF-alpha down-regulated CC chemokine receptor (CCR)1, CCR2, and CCR5 and
up-regulated CCR7 mRNA levels, in agreement with functional data
Sato et al., J Immunol 2000
:
Stimulation of mature DCs with TGF-beta 1 also enhanced TNF-alpha induced down-regulation of the expressions of CCR-1, CCR-3, CCR-5, CCR-6, and CXCR-4, and chemotaxis to their respective ligands, while this stimulation suppressed
TNF-alpha induced expression of
CCR-7 and chemotactic migratory ability to MIP-3 beta
Croitoru-Lamoury et al., Glia 2003
:
Moreover,
TNFalpha and IL-1beta significantly
increase BOB/GPR15,
CCR2 , and V28/CX3CR1 mRNA levels in both models
Boislève et al., J Invest Dermatol 2004
(MAP Kinase Signaling System) :
CCR7 expression was strongly
dependent on
TNF-alpha in the case of DNCB, however, neutralization of TNF-alpha only partially reduced CCR7 expression upon NiSO ( 4 ) treatment
Ponte et al., Stem Cells 2007
:
TNFalpha increases CCR2,
CCR3 , and CCR4 expression ( as opposed to that of CXCR4 ), together with RANTES membrane binding
Catley et al., IDrugs 2010
(Asthma...) :
This conference report highlights selected presentations on mAb treatments for asthma, including targeting IL-5, IL-13, IL-9 and
TNFa ,
CCR3 inhibitors , histamine H4 receptor inhibition, novel mouse models of COPD and inhaled antisense asthma therapies