◀ Back to MAPK4

LPA — MAPK4

Text-mined interactions from Literome

Mattingly et al., Cell Signal 1999 (Calcium Signaling) : The stimulation of Ras-GRF can be demonstrated in vitro, in an assay using recombinant Ras substrate, and in situ, by a selective increase in the ability of LPA to stimulate mitogen activated protein ( MAP ) kinase
Kim et al., J Cell Biochem 2000 (Calcium Signaling) : LPA stimulated MAPK signaling was suppressed by the selective EGF receptor inhibitor and in the dominant negative mutant EGF receptor cell line
Sekharam et al., Biochem J 2000 : Unlike LPA induced mitogen activated protein ( MAP ) kinase activation, LPA stimulated H ( 2 ) O ( 2 ) release was independent of the tyrosine kinase activity of the epidermal growth factor (EGF) receptor
Lee et al., Am J Physiol Cell Physiol 2000 (Calcium Signaling) : LPA and S1P also stimulated intracellular Ca ( 2+ ) mobilization and mitogen activated protein kinase ( MAPK ) phosphorylation
Fitzgerald et al., Biochem Biophys Res Commun 2000 : LPA also induced phosphorylation of mitogen activated protein kinase ( p42(MAPK) and p44(MAPK) ) in HOFNH30 transfected but not vector transfected RBL-2H3 cells
Zippel et al., Exp Cell Res 2000 (Calcium Signaling) : Moreover, in NIH 3T3 fibroblasts it potentiates the effect of lysophosphatidic acid (LPA) on Ras protein and MAPK activity
Huang et al., Arch Biochem Biophys 2000 : In this work, we examined possible interactions between the effects of EtOH and LPA on DNA synthesis, cell proliferation, activating phosphorylation of p44/p42 mitogen activated protein kinases ( MAPK ), and p70 S6 kinase (p70 S6K) activity
Ishii et al., Mol Pharmacol 2000 : Each of the receptors could couple to multiple G-proteins and induced LPA dependent inositol phosphate production, mitogen activated protein kinase activation , and arachidonic acid release while inhibiting forskolin induced cAMP accumulation, although the efficacy and potency of LPA varied from receptor to receptor
Derkinderen et al., J Neurochem 2001 : In contrast, lysophosphatidic acid (LPA) , a lipid messenger acting on different receptors, increased both p38-MAPK and JNK phosphorylation
Mattingly et al., Cell Signal 2001 (MAP Kinase Signaling System...) : In SKNSH rDOX6 cells, decreased activation and reduced nuclear translocation of MAPk in response to EGF, or lysophosphatidic acid (LPA) , or phorbol 12-myristate 13-acetate ( PMA ), were observed
Yart et al., J Biol Chem 2002 : We have observed that dominant negative mutants of p110beta, but not of p110gamma, inhibited MAPK stimulation in response to lysophosphatidic acid (LPA)
Grey et al., Endocrinology 2002 : Specific inhibitors of p42/44 MAPK signaling did not block LPA- or S1P induced osteoblast survival
Moughal et al., Cell Signal 2004 (MAP Kinase Signaling System) : Third, the over-expression of recombinant LPA ( 1 ) receptor potentiated LPA- and NGF dependent activation of p42/p44 MAPK
Gruber et al., J Dent Res 2004 (MAP Kinase Signaling System) : Effects of LPA on proliferation, differentiation, and mitogen activated protein kinase ( MAPK ) signaling of dental pulp fibroblasts ( DPF ) were examined in vitro ... Involvement of extracellular signal regulated kinase, p38 MAPK , and c-Jun NH ( 2 ) -terminal kinase in LPA signaling could be demonstrated by use of specific inhibitors and detection of the phosphorylation status of the kinases
Miyamoto et al., Cancer Res 2004 (Ovarian Neoplasms) : LPA , which is constitutively produced by ovarian cancer cells, induced HB-EGF ectodomain shedding in SKOV3 and RMG-1 cells, resulting in the transactivation of EGFR and the downstream kinase extracellular signal regulated kinase/mitogen activated protein kinase
Moughal et al., J Neurochem 2006 : Ki16425 reduced the LPA induced activation of p42/p44 mitogen activated protein kinase ( MAPK ), while acting as a weak stimulator of p42/p44 MAPK on its own, properties typical of a protean agonist ... In contrast, the stimulation of PC12 cells with LPA leads to a predominant G ( i ) alpha2 mediated Trk A-independent activation of p42/p44 MAPK , where Gbetagamma subunits play a diminished role
Brault et al., Am J Physiol Regul Integr Comp Physiol 2007 : LPA decreased intracellular GSH levels and induced a p38 MAPK/JNK dependent inducible nitric oxide synthase (NOS) expression
Estrella et al., Int J Oncol 2007 (MAP Kinase Signaling System...) : LPA stimulation of ovarian cancer cells markedly increased the phosphorylation and activity of p38 ( MAPK ), p42/p44(MAPK), and PI3K
Billon-Denis et al., J Lipid Res 2008 (Leiomyoma...) : LPA and scPLD induced extracellular signal regulated kinase ( ERK ( 1/2 ) ) mitogen activated protein kinase activation
Kalari et al., Am J Physiol Lung Cell Mol Physiol 2009 (MAP Kinase Signaling System) : Furthermore, downregulation of native AGK by AGK small interfering RNA decreased intracellular LPA levels ( approximately 2-fold ) and attenuated LPA induced p38 MAPK , JNK, and NF-kappaB activation, tyrosine phosphorylation of EGF-R, and IL-8 secretion
Windischhofer et al., Biochimie 2012 (MAP Kinase Signaling System...) : As LPA may induce cellular reponses in human osteosarcoma, the present study aimed at investigating expression of various LPA receptors, LPA mediated activation of MAPK via G-protein coupling, and expression of early response genes in a cellular model for human osteosarcoma ... Using pharmacological inhibitors, we show that LPA mediated phosphorylation of p42/44 MAPK by LPA receptor engagement is transmitted by G ( ai ) -dependent pathways through the Src family of tyrosine kinases
Hordijk et al., J Biol Chem 1994 : Furthermore, LPA , like epidermal growth factor, causes tyrosine phosphorylation and activation of the p42/p44 mitogen activated protein ( MAP ) kinases , paralleling p21ras activation
Rosskopf et al., Am J Physiol 1998 : LPA stimulated a strong increase in the specific phosphorylation of the mitogen activated protein kinase ( immunoblot analysis ) that was prevented by the MEK inhibitor PD-98059
Buist et al., Biochem Biophys Res Commun 1998 (Neuroectodermal Tumors, Primitive, Peripheral) : Lysophosphatidic acid (LPA) and endothelin-1 (ET-1), two ligands for G-protein coupled receptors ( GPCRs ), induce activation of mitogen activated protein kinase ( MAPK ) ... Surprisingly, LPA and ET-1 did not induce MAPK activation in SK-N-MC neuroepithelioma cells, even though these GPCR ligands evoked a rapid, transient rise in intracellular free Ca2+ concentration in these cells, indicating that SK-N-MC cells express functional LPA- and ET-1-receptors
Mondorf et al., FEBS Lett 1998 : When protein kinase C ( PKC ) was depleted by long-term incubation with the phorbol 12-O-myristate 13-acetate the effect of Lp(a) on MAPK activation was completely inhibited ... Forskolin, a stimulator of the adenylyl cyclase, and dibutyryl-cAMP reduced the effect of Lp(a) on MAPK phosphorylation and activation