◀ Back to TP53

CDC25A — TP53

Text-mined interactions from Literome

Levesque et al., Mol Cancer Ther 2008 (Neoplasms) : Surprisingly, incubation of MCF10A immortalized breast cells with UCN-01 fails to elevate Cdc25A protein due to p53 mediated inhibition of Cdc25A transcription
Demidova et al., J Biol Chem 2009 : Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control ... We show that activation of tumor suppressor p53 by DNA damage results in inhibition of Cdc25A transcription as a result of activation of transcriptional repressor ATF3 that directly binds to the Cdc25A promoter
Chiu et al., Anticancer Res 2009 (Carcinoma, Squamous Cell...) : Treatment with 30 microM of aloe-emodin led to S-phase arrest through promoted p53 , p21 and p27, but inhibited cyclin A, E, thymidylate synthase and Cdc25A levels
Foskolou et al., Oncogene 2013 (Neuroblastoma) : Most importantly, Prox1 was sufficient to decrease Cdc25A and induce p27-Kip1, but not p21-Cip1 or p53