Gene interactions and pathways from curated databases and text-mining

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PPARA — SREBF1

Text-mined interactions from Literome

Yoshikawa et al., Mol Endocrinol 2003 : Luciferase assays in human embryonic kidney 293 cells showed that overexpression of PPARalpha and gamma dose-dependently inhibited SREBP-1c promoter activity induced by LXR
Rampler et al., Mol Genet Metab 2003 (Adrenoleukodystrophy) : A PPARalpha dependent induction of the sterol regulatory binding protein 2 ( SREBP2 ) and a down-regulation of SREBP1c mRNA levels could be demonstrated after fenofibrate treatment of mice
Kim et al., Proc Natl Acad Sci U S A 1998 : We show here that the expression of ADD1/SREBP1 specifically increases the activity of PPARgamma but not other isoforms, PPARalpha , or PPARdelta