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PPM1D — TP53

Pathways - manually collected, often from reviews:

• KEGG p53 signaling pathway: TP53 → PPM1D (gene expression, expression)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: TP53 — PPM1D (in vivo) Lu et al., Cancer Cell 2007*

Text-mined interactions from Literome

Lu et al., Mol Cell 2004 : The wild-type p53 induced phosphatase PPM1D ( or Wip1 ) is a serine/threonine phosphatase that is transcriptionally upregulated by p53 following ultraviolet and ionizing radiation
Lu et al., Cell cycle (Georgetown, Tex.) 2004 (Breast Neoplasms...) : PPM1D may inhibit p53 activity through inactivating dephosphorylation of the p38 MAP kinase
Lu et al., Cell cycle (Georgetown, Tex.) 2005 : Because PPM1D is transcriptionally activated by p53 in response to DNA damage, PPM1D may serve as a critical component of a p53 negative feedback regulatory loop since it now appears that PPM1D can inhibit p53 activity by at least four different molecular mechanisms
Lu et al., Cancer Cell 2007 (Osteosarcoma) : Here we show that the wild-type p53 induced phosphatase 1 ( Wip1 ), or PPM1D , downregulates p53 protein levels by stabilizing Mdm2 and facilitating its access to p53
Pärssinen et al., Cancer Genet Cytogenet 2008 (Breast Neoplasms) : Our findings demonstrate that PPM1D is involved in the regulation of cell proliferation in breast cancer in a p53 dependent manner and that overexpression of PPM1D contributes to malignant phenotype by promoting sustained cell growth and cell survival
Nguyen et al., DNA repair 2010 : Therefore, we investigated whether the serine/threonine wild-type p53 induced phosphatase 1 ( WIP1/PPM1D ) might regulate NER