Ripp et al., Mol Pharmacol 2003
:
In HepG2 cells, negative regulation of a CYP2C11 reporter gene by nafenopin required coexpression of PPARalpha , whereas negative regulation by DHEA did not
Shaban et al., Xenobiotica 2005
:
To the best of the authors ' knowledge, this is the first study showing the presence of mutual effects of AhR and PPARalpha on CYP2B and CYP3A and an additive inhibitory effect on CYP2C11 in the livers of male rats
Pozzi et al., J Biol Chem 2007
(Cell Transformation, Neoplastic...) :
PPARalpha also regulates the expression of Cyp4a fatty acid omega-hydroxylases and Cyp2c arachidonic acid epoxygenase genes