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ALOX12 — EGF

Text-mined interactions from Literome

Chang et al., Biochem Biophys Res Commun 2005 : Treatment of human epidermoid carcinoma A431 cells with EGF induces the gene expression of human 12(S)-lipoxygenase, and two Sp1 binding sites residing at -158 to -150 bp and -123 to -114 bp are essential in the mediation of EGF induction of the 12(S)-lipoxygenase gene
Chen et al., Eur J Pharmacol 2008 : The mechanism by which the histone deacetylase (HDAC) inhibitor trichostatin A inhibits epidermal growth factor (EGF) induced human 12(S)-lipoxygenase expression was studied ... Trichostatin A treatment of human epidermoid carcinoma A431 cells inhibited the EGF induced 12(S)-lipoxygenase enzymatic activity in a dose dependent manner that was consistent with the expression of 12(S)-lipoxygenase mRNA and protein ... These results suggested that trichostatin A inhibited EGF induced 12(S)-lipoxygenase expression by multiple mechanisms, including the attenuation of c-Jun and Sp1 expression and p300 recruitment to the 12(S)-lipoxygenase gene promoter
Huang et al., Cell Mol Life Sci 2010 : EGF induced promoter activity and the mRNA level of 12(S)-lipoxygenase as well as the association between c-Jun and Sp1 were reduced by ARNT knockdown