Gene interactions and pathways from curated databases and text-mining

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LTB — RELA

Text-mined interactions from Literome

Müller et al., J Biol Chem 2003 : Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways ... Lymphotoxin beta receptor (LTbetaR) induced activation of NF-kappaB in mouse embryo fibroblasts was mediated by the classical pathway and by an alternative or second pathway
Huang et al., Arterioscler Thromb Vasc Biol 2004 : Furthermore, LTB4 increased NF-[kappa]B DNA binding activity, which was blocked by CP-105,696
Shim et al., Genes Dev 2005 : However, TAK1 is not required for NF-kappaB activation through the alternative pathway following LT-beta signaling
Kanda et al., Clin Exp Allergy 2007 : LTB ( 4 ) alone did not enhance CCL27 production and modestly enhanced NF-kappaB activity in human keratinocytes ... However, LTB ( 4 ) potently enhanced TNF-alpha induced CCL27 secretion and mRNA expression and NF-kappaB activity
Dhawan et al., J Biol Chem 2008 (Melanoma...) : These results indicate that the LTbeta-R constitutively induces NF-kappaB activation, and this event may be associated with autonomous growth of melanoma cells
Vallabhapurapu et al., Eur J Immunol 2008 : NF-kappaB also regulates TCR induced expression of LT-alpha and LT-beta within NKT cells
Razani et al., Science signaling 2010 : Here, we describe a mechanism of negative feedback control of noncanonical NF-kappaB signaling that attenuated the stabilization of NF-kappaB inducing kinase (NIK) , the central regulatory kinase of the noncanonical pathway, induced by B cell activating factor receptor ( BAFF-R ) and lymphotoxin beta receptor (LTbetaR)
Mackay et al., J Biol Chem 1996 : Here, we show that engagement of LTbeta-R with a soluble form of LTalpha1beta2 or with a specific anti-LTbeta-R agonistic monoclonal antibody CBE11 quickly induces activation of NFkappaB in HT-29 and WiDr human adenocarcinomas ... LTbeta-R triggering activates NFkappaB and induces proliferation in WI-38 human lung fibroblasts ... Thus, like several other members of the TNF receptor family, the LTbeta-R can activate NFkappaB following receptor ligation in some but not all LTbeta-R positive cells
Ware et al., J Cell Biochem 1996 : The TRAF family of Zn RING/finger proteins bind to TNFR80 ; CD40 and LT beta R are involved in induction NF kappa B and cell survival
VanArsdale et al., Proc Natl Acad Sci U S A 1997 (Adenocarcinoma) : The binding of heterotrimeric lymphotoxin, LT alpha1 beta2, to the LTbeta receptor (LTbeta R) , a member of the tumor necrosis factor receptor (TNFR) superfamily, induces nuclear factor kappaB (NF-kappaB) activation and cell death in HT29 adenocarcinoma cells