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IL10 — MAP3K7
Text-mined interactions from Literome
Frobøse et al., Mol Endocrinol 2006
:
Suppressor of cytokine Signaling-3
inhibits interleukin-1 signaling by targeting the
TRAF-6/TAK1 complex
Thiefes et al., EMBO Rep 2006
:
YopP, but not the catalytically inactive mutant YopP ( C172A ), also suppresses basal and
interleukin-1-inducible activation of endogenous
TAK1 , TAB1 and TAB2
Inagaki et al., J Biol Chem 2008
:
Tumor necrosis factor- and
interleukin-1 induced
activation of
TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
Kim et al., PloS one 2009
(Colitis) :
Finally, we showed that
TAK1 is
essential for
interleukin 1- and bacterial components induced expression of cytoprotective factors such as interleukin 6 and cycloxygenase 2
Eftychi et al., PloS one 2012
(Endotoxemia) :
Myeloid-specific
TAK1 deficiency in mice leads to increased levels of circulating IL-1ß, TNF and
reduced IL-10 after LPS challenge and sensitizes them to LPS induced endotoxemia