Gene interactions and pathways from curated databases and text-mining

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CCL4 — IL10

Text-mined interactions from Literome

Wang et al., J Immunol 1999 : IL-4, IL-10 , IFN-gamma, and IL-18 primarily inhibited MIP-1beta secretion and also weakly suppressed MIP-1alpha secretion
Olszyna et al., J Infect Dis 2000 (Endotoxemia) : Sixteen healthy subjects were intravenously injected with lipopolysaccharide (LPS), once with placebo and once with recombinant human interleukin (IL)-10 ( 25 microgram/kg ), to determine the effect of IL-10 on LPS induced production of macrophage inflammatory protein (MIP)-1alpha, MIP-1beta , and monocyte chemoattractant protein (MCP)-1
Lapinet et al., Infect Immun 2000 (Meningitis, Meningococcal) : In line with its downregulatory effects on neutrophil derived proinflammatory cytokines, IL-10 potently inhibited TNF-alpha, IL-1beta, IL-8, and MIP-1beta production triggered by OMV
Tamassia et al., Int Immunol 2008 (Sepsis...) : Consistent with the presence of a fully functional IL-10R, modulation of LPS induced CXCL8, CCL4 , tumour necrosis factor-alpha and IL-1ra gene expression was also rapidly induced by IL-10 in septic, but not normal, neutrophils