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IL2 — PPARA

Text-mined interactions from Literome

Daynes et al., Antioxid Redox Signal 2003 : Lower PPARalpha levels are present in aged CD4+ T cells, and appear responsible for the suppressed interleukin-2 and exaggerated IFNgamma responses by these cells
Raman et al., Mol Pharmacol 2011 : 2-AG mediated IL-2 suppression is dependent on cyclooxygenase-2 (COX-2) metabolism and peroxisome proliferator activated receptor ? ( PPAR? ) activation
Borland et al., Cell Signal 2011 : However, these studies demonstrate that stable over-expression of PPARß/d or PPAR? significantly increases the efficacy of ligand activation and represses UVB induced expression of tumor necrosis factor a (TNFa), interleukin 6 (IL6), or IL8 in HaCaT keratinocytes, thereby establishing an excellent model to study the functional role of these receptors in human keratinocytes
Martín et al., J Hypertens 2012 : In addition, pioglitazone increased the interleukin-1ß induced PPAR? mRNA levels