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CAV2 — MAPK3
Text-mined interactions from Literome
Minelli et al., Peptides 2006
:
It greatly
enhances the phosphorylation of hsp27, alpha-B-crystallin, Cdc2, and p-38
MAPK , whereas it decreases the phosphorylation of MEK1,
Cav 2 , GSK3a, PKB/Akt, PKCdelta, PKCgamma, and Erk2
Wang et al., Am J Respir Cell Mol Biol 2006
(Inflammation) :
p38
mitogen activated protein kinase ( MAPK ) phosphorylation was
increased by overexpressing
caveolin-1 in RAW264.7 cells, whereas c-Jun N-terminal kinase, extracellular signal regulated kinase MAPK, and Akt phosphorylation were inhibited
Wang et al., Am J Pathol 2007
:
Therefore, human immunodeficiency virus protease inhibitor ritonavir significantly inhibits cholesterol efflux from macrophages, which may be mediated by mitochondrial dysfunction, oxidative stress,
ERK1/2 activation , and down-regulation of scavenger receptor B1 and
caveolin-1
Chen et al., Oncogene 2009
(Neoplasm Invasiveness...) :
Further study revealed that the upregulation of
caveolin-1 and inhibition of tumor cell invasion were
mediated by reactive oxygen species induced p38
MAPK activation
Wu et al., J Cell Biochem 2009
:
The increase in
caveolin-1 expression was
dependent on phosphorylation of the mitogen activated protein kinases ( MAPKs )
extracellular signal regulated kinase1/2 ( ERK1/2 ), p38, and Jun N-terminal kinase (JNK) and the transcriptional activation and translocation of nuclear factor- ? B ( NF-kappaB )
Lv et al., Inflamm Res 2010
(Inflammation) :
Over-expression of
caveolin-1 not only increased the production of pro-inflammatory cytokine TNF-alpha and IL-6, but also
enhanced the expression of the cPLA2, p38
MAPK , and NF-kappaB
Chi et al., Future Microbiol 2011
(Disease Models, Animal...) :
Furthermore, E44 invasion, E44/nicotine induced
activation of
Erk1/2 and clustering of a7 nAChR and
caveolin-1 was specifically blocked by both siRNAs
Jagielska et al., Arterioscler Thromb Vasc Biol 2012
(Disease Models, Animal...) :
Accordingly, cellular cholesterol depletion ( cyclodextrin ) and silencing of
caveolin-1 ( small interfering RNA )
inhibited IL-1ß induced activation of
p38-MAPK and MK2, as well as IL-1ß induced tube formation and migration