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IL10 — TAT

Text-mined interactions from Literome

Kutsch et al., J Virol 2000 (HIV Infections) : Herein, we demonstrate that HIV-1 Tat ( 72aa ) is a potent inducer of MCP-1, interleukin-8 (IL-8), and IP-10 expression in astrocytes
Badou et al., J Virol 2000 : In the present work, we tested the capacity of Tat to induce IL-10 production by peripheral blood monocytes of healthy donors ... The results show that Tat causes the production of IL-10 in a dose- and stimulation time dependent manner ... This production of IL-10 induced by Tat could participate in the progression of HIV infection to AIDS
Bennasser et al., J Soc Biol 2001 : We show that HIV-1 Tat , a viral protein secreted by infected cells, induces IL-10 production by human peripheral blood monocytes
Bennasser et al., FASEB J 2002 : We have previously shown that HIV-1 Tat induces IL-10 production by human monocytes via a protein kinase C ( PKC ) -dependent pathway ... Here we show that PKC activation by Tat is essential for IL-10 induction ... Among the eight PKC isoforms present in human monocytes, we investigated which isoform ( s ) plays this crucial role in Tat mediated IL-10 production and show that 1 ) Tat can activate PKC-alpha, PKC-betaII, PKC-delta, and PKC-epsilon, 2 ) of these four potential candidates, only PKC-betaII, PKC-delta, and PKC-epsilon are activated by the active domain Tat 1-45, which is responsible for IL-10 production and depleted by long-term exposure to PMA, which abolishes Tat mediated IL-10 production, 3 ) whereas selective inhibition of PKC-alpha and PKC-epsilon by specific antisense oligonucleotides has no effect on Tat mediated IL-10 induction, inhibition of either PKC-betaII or PKC-delta partially inhibits IL-10 production ; and 4 ) the simultaneous inhibition of PKC-betaII and PKC-delta totally inhibits Tat mediated IL-10 ... Altogether, these results suggest that the induction of IL-10 by Tat is strictly dependent on the PKC-delta and -betaII isoforms
Contreras et al., Microbes Infect 2004 : IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta ( II ) and delta isozymes
Gee et al., J Biol Chem 2006 (MAP Kinase Signaling System) : Intracellular HIV-Tat expression induces IL-10 synthesis by the CREB-1 transcription factor through Ser133 phosphorylation and its regulation by the ERK1/2 MAPK in human monocytic cells ... The signaling pathways involved in the regulation of IL-10 production by endogenous Tat remain unknown ... To understand the molecular mechanism underlying intracellular Tat induced IL-10 transcription, we employed a retroviral expression system to investigate the role of MAPKs and the transcription factor ( s ) involved ... Our results suggest that an inhibitor specific for the ERK1/2, PD98059, selectively blocked intracellular Tat induced IL-10 expression in THP-1 cells ... Overall, our results suggest that intracellular HIV-Tat induces IL-10 transcription by ERK MAPK dependent CREB-1 transcription factor activation through Ser ( 133 ) phosphorylation
Gee et al., J Immunol 2007 : IL-10 regulation by HIV-Tat in primary human monocytic cells : involvement of calmodulin/calmodulin dependent protein kinase activated p38 MAPK and Sp-1 and CREB-1 transcription factors ... Herein, we show that extracellular Tat induced IL-10 expression in normal human monocytes ... The experiments designed to further understand the molecules involved in the calcium signaling suggested that calmodulin and calmodulin dependent protein kinase-II ( CaMK-II ) -activated p38 MAPK played a role in extracellular Tat induced IL-10 expression in primary human monocytes ... Furthermore, Tat induced IL-10 expression was regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors
Li et al., Immunology 2007 : A role for mitogen activated protein kinase and Ets-1 in the induction of interleukin-10 transcription by human immunodeficiency virus-1 Tat ... We recently demonstrated that HIV-1 Tat induces the expression of interleukin (IL)-10 via p38 mitogen activated protein kinase ( MAPK ) activation ... In conclusion, the coordinated activities of p38 MAPK and the transcription factors, Ets-1 and Sp-1, may play an important role in the HIV-1 Tat induced IL-10 transcription
Gupta et al., J Immunol 2008 (HIV Infections) : Analysis of the cytokine profile suggests that Tat induces IL-10 and since IL-10 has been demonstrated to have appreciable T cell inhibitory activity, it is plausible that IL-10 could be responsible for Tat mediated immunosuppression
Leghmari et al., Cell Immunol 2008 : Our data showed that ( i ) in the presence of neutralizing anti-TNF-alpha antibodies, IL-10 production is only partially inhibited ; ( ii ) in a calcium-free medium, while TNF-alpha production is totally inhibited, Tat continues to induce IL-10 ; ( iii ) under these conditions, Tat mediated IL-10 production is associated with PKC-delta activation ; and ( iv ) downstream of PKC, p38 MAP kinase is crucial for TNF-alpha independent IL10 production
Leghmari et al., Eur J Cell Biol 2008 : Here, we show that, by acting at the membrane, Tat induces IL-10 expression in primary monocytes and promonocytic U937 cells by NF-kappaB dependent pathways
Wong et al., J Biol Chem 2010 (Inflammation) : Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins ... Moreover, we show that p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat induced IL-10 production
Poggi et al., J Biol Chem 1998 : Here we demonstrate that Tat inhibits apoptotic body engulfment and interleukin-12 production by blocking extracellular calcium influx
Ito et al., AIDS Res Hum Retroviruses 1998 : Tat at the same concentrations did not affect IL-10 , IL-6, or TNF-alpha production