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CHUK — TNFSF11
Text-mined interactions from Literome
Lee et al., Mol Cell Biochem 2006
:
Osteoclast precursors expressing a dominant negative Rac1N17 are defective in
TRANCE induced
IKK activation and IkappaBalpha degradation resulting in inhibition of NFkappaB dependent reporter gene activity
Besse et al., J Biol Chem 2007
:
A green fluorescent protein fusion protein containing the last 100 residues of TAK1 ( TAK1-C100 ) abolished the interaction of endogenous TAB2/TAB3 with TAK1, the phosphorylation of TAK1, and prevented the activation of
IKK and MAPK
induced by IL-1, TNF, and
RANKL
Reuter et al., Br J Pharmacol 2012
(Bone Neoplasms...) :
Inhibition of the NF-?B pathway was responsible for this effect since the colchicoside inhibited
RANKL induced NF-?B activation, activation of I?B kinase (
IKK ) and suppressed inhibitor of NF-?Ba ( I?Ba ) phosphorylation and degradation, an inhibitor of NF-?B
Liu et al., Int Immunopharmacol 2012
(Bone Resorption...) :
Furthermore,
RANKL mediated
increase of
IKK , I?Ba, and p65 phosphorylation and NF-?B-luciferase activity was inhibited by D-pinitol
Hsiao et al., Osteoporos Int 2013
(Bone Resorption...) :
Kinsenoside significantly inhibits the
RANKL induction of
IKK activity