Vaccari et al., Development 2010
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These data indicate that V-ATPase , probably via acidification of early endosomes, promotes not only the degradation of Notch in the lysosome but also the activation of Notch signaling in endosomes
Sethi et al., J Biol Chem 2010
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Pharmacological inhibition of the V-ATPase complex significantly reduced Notch signaling in mammalian cells
Lange et al., Stem Cells Dev 2011
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Moreover, inhibition of the v-ATPase reduced endogenous Notch signaling and prevented the proliferative effect of a transmembrane, ?-secretase dependent, active Notch without blocking the effects of its cytoplasmic intracellular domain ( NICD )