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EPHB2 — MMP1

Text-mined interactions from Literome

Brauchle et al., Exp Cell Res 2000 : Independent role of p38 and ERK1/2 mitogen activated kinases in the upregulation of matrix metalloproteinase-1
Reunanen et al., J Biol Chem 2002 : Activation of endogenous ERK1/2 by adenovirus mediated transfer of constitutively active MEK1 resulted in potent induction of MMP-1 and MMP-3 expression
Benbow et al., J Cell Biochem 2002 (Melanoma...) : High levels of MMP-1 expression in the absence of the 2G single nucleotide polymorphism is mediated by p38 and ERK1/2 mitogen activated protein kinases in VMM5 melanoma cells
Lai et al., J Immunol 2003 : Thus, LPS induction of MMP-1 production by monocytes is regulated by both ERK1/2 and p38, whereas MMP-9 stimulation occurred mainly through the ERK1/2 pathway
Utani et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Studies with specific inhibitors of MAPKs showed that p38 MAPK activation was necessary for both IL-1 beta and MMP-1 induction, but Erk activation was required only for MMP-1 induction
Pillinger et al., J Immunol 2003 : Pharmacologic inhibitors of ERK inhibited MMP-1 , but not MMP-13 expression ... Whereas millimolar salicylates inhibited both ERK and MMP-1, nonsalicylate COX and selective COX-2 inhibitors enhanced stimulated MMP-1 release ... Addition of exogenous PGE ( 1 ) or PGE ( 2 ) inhibited MMP-1 , reversed the effects of COX inhibitors, and inhibited ERK activation, suggesting that COX-2 activity tonically inhibits MMP-1 production via ERK inhibition by E PGs ... Exposure of FLSCs to nonselective COX and selective COX-2 inhibitors in the absence of stimulation resulted in up-regulation of MMP-1 expression in an ERK dependent manner ... Our data indicate that : 1 ) ERK activation mediates MMP-1 but not MMP-13 release from FLSCs, 2 ) COX-2 derived E PGs inhibit MMP-1 release from FLSCs via inhibition of ERK, and 3 ) COX inhibitors, by attenuating PGE inhibition of ERK, enhance the release of MMP-1 by FLSC
Sylvester et al., Cell Signal 2004 : ERK pathway inhibitors, PD98059 and U0126, down-regulated IL-17 induced MMP and ADAM-TS4 gene expression
Mercer et al., J Biol Chem 2004 (MAP Kinase Signaling System) : The identification of active ERK in the lungs of emphysema patients and the finding that induction of MMP-1 by cigarette smoke in pulmonary epithelial cells is ERK dependent reveal a molecular mechanism and potential therapeutic target for excessive matrix remodeling in smokers who develop emphysema
Kunapuli et al., J Biol Chem 2004 (Glioma...) : Inhibition of the MAPK pathway using the pharmacological inhibitors PD98059, U0126, and SB203580 in T98G LGI1-null cells inhibits MMP1 and MMP3 production in an ERK1/2 dependent manner
Shah et al., Mol Endocrinol 2004 : Agonist mediated MMP activation in C9 cells led to shedding of heparin binding EGF (HB-EGF) and stimulation of ERK1/2 phosphorylation
Purdom et al., J Pharmacol Exp Ther 2005 : In HFs, MMP inhibitors GM6001 [ N- [ ( 2R ) -2- ( hydroxamidocarbonylmethyl ) -4-methylpentanoyl ] -l-tryptophan methylamide ] and BB2516 [ [ 2S- [ N4 ( R ( * ) ) ,2R ( * ) ,3S ( * ) ] ] -N4- [ 2,2-dimethyl-1- [ ( methylamino ) carbonyl ] propyl ] -N1,2-dihydroxy-3- ( 2-methylpropyl ) butanediamide, marimastat ] inhibited JNKs and ERK1/2 activation without affecting p38 activation by H ( 2 ) O ( 2 ) inhibitors
Park et al., J Invest Dermatol 2004 (MAP Kinase Signaling System) : Taken together, our results suggest that ERK and JNK play an important role in the induction of MMP-1 and MMP-3 by heat shock and that the heat shock induced expression of MMP-1 and MMP-3 is mediated via an IL-6 dependent autocrine mechanism
Pillinger et al., J Biol Chem 2005 (Inflammation...) : MMP-1 secretion required activation of the MAPK Erk and subsequent protein synthesis but was down-regulated by the alternate MAPK, p38 ... MMP-1 secretion was regulated by E prostaglandins ( PGEs ) in an Erk dependent manner ... PGEs enhanced Erk activation and MMP-1 secretion in response to EGF but inhibited Erk and MMP-1 when TNF-alpha and IL-1beta were the stimuli, indicating that the effects of PGEs on gastric cell responses are context dependent
Kim et al., J Lipid Res 2005 : Pretreatment of HDFs with EPA inhibited UV-induced MMP-1 expression in a dose dependent manner and also inhibited the UV-induced activation of ERK and JNK by inhibiting ERK kinase ( MEK1 ) and SAPK/ERK kinase 1 (SEK1) activation, respectively
Izbicka et al., Anticancer Res 2005 (Breast Neoplasms...) : R115777 +/- paclitaxel inhibited HDJ-2 farnesylation, up-regulated RhoB, transiently lowered ( P ) ERK/ERK and ( P ) Akt/Akt, reduced Raf-1 and MEK and inhibited secretion of VEGF and MMP-1
Spallarossa et al., Cardiovasc Res 2006 (MAP Kinase Signaling System) : To investigate the signaling pathways leading to doxorubicin induced MMP activation, we also examined the phosphorylation of three members of the MAPK family ( ERK1/2, p38, and JNK ), the effects of selective inhibitors of ERK1/2 , p38, and JNK on MMP transcription and activity, the transcription of the NAD ( P ) H oxidase subunit Nox1, and the effects of the NAD ( P ) H oxidase inhibitor DPI on MMP activation
Shah et al., J Neurochem 2006 : Phe induced phosphorylation of the EGF-R, and subsequently of Shc and ERK1/2 , was attenuated by inhibition of MMP or HB-EGF with the selective inhibitor, CRM197, or by a neutralizing antibody ... In contrast, phosphorylation of the EGF-R, Shc and ERK1/2 by EGF and HB-EGF was independent of PKC and MMP activity
Moon et al., FEBS Lett 2006 : We found that UV irradiation increases MMP-1 expression and that this is mediated by ERK and JNK activation, but not by p38 activation ... Pretreatment of HSFs with 2',4',7-THF inhibited UV-induced MMP-1 expression in a dose dependent manner, and also inhibited the UV-induced activations of ERK and JNK by inhibiting MEK1 and SEK1 activation, respectively
Raymond et al., J Cell Physiol 2006 (MAP Kinase Signaling System) : Interleukin-1 beta induction of matrix metalloproteinase-1 transcription in chondrocytes requires ERK dependent activation of CCAAT enhancer binding protein-beta
Fan et al., Rheumatol Int 2006 : Inhibitors of ERK and NFkappaB could significantly block the induction of MMP-1 and -13 ( p < 0.05 ) and the repression of collagen type II ( p < 0.01 )
Yang et al., J Pharmacol Exp Ther 2006 (Stomach Ulcer) : rCRAMP also increased EGFR and ERK1/2 phosphorylation via an MMP dependent mechanism
Aitken et al., Am J Pathol 2006 (Mechanotransduction, Cellular) : Similarly, stretching BSMCs in vitro induced increases in ERK1/2 activation and ERK1/2 dependent proliferation under discrete mechanical conditions, and distension conditioned medium itself induced MMP dependent ERK1/2 activation in BSMCs. Overall, stretch induced proliferation and ERK1/2 signaling in bladder tissue and BSMCs likely depend on secreted MMP activity
Meriane et al., Stem Cells 2006 (MAP Kinase Signaling System) : Moreover, MMP- and ROCK dependent molecular events are implicated in the regulation of the S1P induced activation of ERK
Séguin et al., Matrix Biol 2006 (Disease Models, Animal...) : We demonstrate that in nucleus pulposus cells, the p38 and JNK pathways regulate induction of MMP-1 and -3 ; p38, JNK, and NF-kappaB regulate the induction of MMP-13 ; and ERK regulates the up-regulation of MT1-MMP mRNA in response to TNFalpha
Lee et al., Life Sci 2006 : In a consistent result, the TNF alpha induced MMP-1 expression was inhibited by PD98059 ( MEK/ERK inhibitor ) and SP600125 ( JNK inhibitor ), but was not inhibited by SB203580, a p38 MAPK inhibitor
Lin et al., J Biol Chem 2008 : This study provides the first evidence that MMP mediated cleavage of EphB2 is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses
Xie et al., Am J Physiol Gastrointest Liver Physiol 2009 (Colonic Neoplasms) : ACh induced MMP1, MMP7 , and MMP10 gene transcription was attenuated by atropine, anti-EGFR antibody, and chemical inhibitors of EGFR and ERK activation ... ACh induced MMP1 , MMP7, and MMP10 gene transcription was attenuated by atropine, anti-EGFR antibody, and chemical inhibitors of EGFR and ERK activation
Shi et al., Am J Physiol Heart Circ Physiol 2010 : Interstitial flow induces MMP-1 expression and vascular SMC migration in collagen I gels via an ERK1/2 dependent and c-Jun mediated mechanism
Sun et al., Molecular cancer 2010 (Chondrosarcoma...) : Chondrosarcoma cell invasion is increased by hypoxia induced expression of CXCR4 and MMP1 and is mediated by HIF-1a and ERK
Bujor et al., Exp Dermatol 2010 : Consistent with the stimulatory role of ERK1/2/Ets1 in the expression of MMP1 , the ERK1/2 inhibitor UO126 prevented the phosphorylation of ERK1/2 and Ets1 and completely abrogated the induction of MMP1 after CCN2 overexpression, while having no effect on c-Jun activation
Pan et al., Zhonghua Kou Qiang Yi Xue Za Zhi 2010 : To investigate the effect of ERK signaling pathway and MMP-9 on migration of hPDLC, the cells were incubated with PD98059, a specific extracellular signal regulated kinase ( ERK ) kinase inhibitor, or doxycycline, a MMP inhibitor
Li et al., Phytomedicine 2010 (Hyperplasia) : However, HG-down regulated MT-1 MMP expression was independent of activation of ERK1/2 and Akt when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination
Ta et al., Atherosclerosis 2010 : DPP-4 ( CD26 ) inhibitor alogliptin inhibits TLR4 mediated ERK activation and ERK dependent MMP-1 expression by U937 histiocytes ... Taken together, this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and ERK dependent MMP expression by U937 cells, suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling
Kim et al., Annals of dermatology 2010 : Furthermore, the inhibition of ERK or JNK with specific chemical inhibitors prevented MßCD induced MMP-1 expression, which indicates that ERK and JNK play an important role in cholesterol depletion mediated MMP-1 induction
Park et al., J Dermatol Sci 2011 (MAP Kinase Signaling System) : Recently, several reports have shown that ERK activity plays an important role in EGF induced MMP-1 expression ... We found that EGF induced MMP-1 expression was positively regulated by JNK as well as ERK but negatively regulated by p38 MAPK in human skin fibroblasts ... Our further studies showed that the inhibition of p38 MAPK but not PI3K specifically increased EGF induced ERK and JNK activations, and that the augmentation of EGF induced MMP-1 expression by p38 MAPK inhibition was significantly attenuated by inhibiting the activities of ERK and/or JNK ... Our results indicate that EGF induced MMP-1 expression is differentially regulated by the JNK, p38 MAPK, and PI3K/Akt pathways, and suggest that p38 MAPK negatively regulates EGF induced MMP-1 expression by suppressing the activations of ERK and JNK
Weiss et al., Cancer Res 2012 (MAP Kinase Signaling System...) : We have determined that TWIST1 acts, in a dose dependent manner, as a mediator between hyperactive ERK1/2 signaling and regulation of MMP-1 transcription
Lee et al., J Biol Chem 2013 (Neoplasm Invasiveness...) : Blockade of p21 ( WAF1 ) function by siRNA reversed migration, invasion, activation of ERK signaling, MMP-9 expression, and activation of NF-?B in IL-20 treated cells
Westermarck et al., Matrix Biol 1998 : In addition, expression of kinase-deficient forms of ERK1,2 , SAPKbeta, p38, or JNK/SAPK kinase SEK1 strongly inhibited OA-elicited activation of MMP-1 promoter ... Results of this study show that MMP-1 gene expression in fibroblasts is coordinately regulated by ERK1,2 , JNK/SAPK, and p38 MAPKs and suggest an important role for the stress activated MAPKs JNK/SAPK and p38 in the activation of MMP-1 gene expression