Zipper et al., Biochem Biophys Res Commun 2000
:
Inhibition of ERK and p38 MAP kinases inhibits binding of Nrf2 and induction of GCS genes ... These studies indicate that ERK and p38 contribute to the transcriptional up-regulation of the GCS subunit genes following PDTC treatment
Jung et al., Exp Mol Med 2009
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Furthermore, MTT and Western blot/immunofluorescence analyses demonstrated that inhibition of the Ugcg expression in mESCs resulted in decrease of cell proliferation ( P < 0.05 ) and decrease of activation of the ERK1/2 ( P < 0.05 ), respectively
Moslehi et al., Cell Mol Neurobiol 2012
(MAP Kinase Signaling System...) :
In addition, our results showed that the exposure of SK-N-MC cells to H ( 2 ) O ( 2 ) ended up in reduction of glutathione ( GSH ) levels of SK-N-MC cells via JNK/ERK mediated down-regulation of ?-glutamyl-cysteine synthetase ( ?-GCS ) expression