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ADH5 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: ADH5 — TP53 (physical association, affinity chromatography technology) Lunardi et al., Proc Natl Acad Sci U S A 2010

Text-mined interactions from Literome

Oleinik et al., Mol Cancer Res 2003 (Carcinoma, Non-Small-Cell Lung...) : Accumulation of intracellular FDH was followed by accumulation of the tumor suppressor protein p53 and its downstream target p21
Oleinik et al., Oncogene 2007 : We have previously shown that FDH induces phosphorylation of p53 at Ser6, which is a required step in the activation of apoptosis ... In the present study, we report that FDH induced p53 phosphorylation is carried out by JNK1 and JNK2 ( c-Jun N-terminal kinases ) working in concert ... We have demonstrated that FDH induces phosphorylation of JNK1 and JNK2, while treatment of FDH expressing cells with JNK inhibitor SP600125, as well as knockdown of JNK1 or JNK2 by siRNA, prevents phosphorylation of p53 at Ser6 and protects cells from apoptosis