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DSG1 — RELA

Text-mined interactions from Literome

Thomas et al., Transplantation 1999 : Day of transplant T cell depletion with anti-CD3 immunotoxin or F ( Ab ) 2 immunotoxin induces stable tolerance to renal allografts in rhesus monkeys given 15-deoxyspergualin (DSG) , a NF-kappaB inhibitor that suppresses proinflammatory cytokine ( PC ) production
Thomas et al., Immunol Rev 2001 : DSG , an inhibitor of HSC 70-mediated NF-kappaB nuclear translocation, arrests maturation of myeloid dendritic cells, blocks production of proinflammatory cytokines induced by IT administration, and promotes systemic production of Th2 type cytokines that persist indefinitely
Shirasugi et al., Transplant Proc 2004 : A virally induced alloreactive memory seems to represent a potent barrier to tolerance induction but the combination of 15-deoxyspergualin (DSG) , an inhibitor of NFkB translocation, with costimulation blockade ( CB ) -based chimerism as an induction regimen can overcome a preformed anti-donor memory response
Tepper et al., J Immunol 1995 : Analysis of nuclear and cytoplasmic NF-kappa B expression using electrophoretic mobility shift analysis and Western analysis, revealed that DSG blocked LPS induced NF-kappa B nuclear translocation, but had no effect on cytoplasmic NF-kappa B levels
Suzuki et al., Nihon Geka Gakkai Zasshi 1996 : DSG may bind to Hsc 70 and inhibit the translocation of NF-kappa B into nucleus