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RELA — TGM2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: Complex of RELA-NFKBIA-TGM2-NFKBIA-RELA-RELA-TGM2-TGM2-NFKBIA (in vivo) Mann et al., Cancer Res 2006*
• IRef Hprd Interaction: RELA — TGM2 (in vivo) Mann et al., Cancer Res 2006*
• IRef Intact Interaction: Complex of TGM2-RELA-NFKBIA (association, anti bait coimmunoprecipitation) Mann et al., Cancer Res 2006*
• IRef Intact Interaction: TGM2 — RELA (physical association, anti bait coimmunoprecipitation) Mann et al., Cancer Res 2006*
• IRef Intact Interaction: TGM2 — RELA (colocalization, confocal microscopy) Mann et al., Cancer Res 2006*

Text-mined interactions from Literome

Lee et al., J Biol Chem 2004 (Inflammation) : We found that TGase 2 activates the transcriptional activator nuclear factor (NF)-kappaB and thereby enhances LPS induced expression of inducible nitric-oxide synthase ... TGase 2 activates NF-kappaB via a novel pathway
Lee et al., Frontiers in bioscience : a journal and virtual library 2006 (Inflammation...) : Previously we showed that the overexpression of transglutaminase 2 (TGase 2) resulted in activation of NF-kappaB through polymerization of I-kappaBalpha
Park et al., J Biol Chem 2006 : Recently we reported that transglutaminase 2 (TGase 2) activates nuclear factor-kappaB (NF-kappaB) independently of I-kappaB kinase (IKK) activation, by inducing cross linking and protein polymer formation of inhibitor of nuclear factor-kappaBalpha ( I-kappaBalpha )
Kim et al., Cancer Res 2006 (Breast Neoplasms) : We recently showed that TGase 2 activated NF-kappaB through polymerization and depletion of free IkappaBalpha during inflammation ... Therefore, increased expression of TGase 2 and subsequent activation of NF-kappaB may contribute to drug resistance in breast cancer cells independently of EGF signaling
Cho et al., Coron Artery Dis 2008 (Coronary Artery Disease) : The objective of the present study was to investigate the expression of TGase 2 in the human atherosclerotic human coronary artery, and the possible roles of TGase 2 in NF-kappaB activation
Kim et al., Biochem Biophys Res Commun 2010 (Neoplasms) : TGase 2 can activate NF-kappaB through the polymerization mediated depletion of I-kappaBalpha without IKK activation