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BIRC3 — CASP3
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
BIRC3
—
CASP3
(experimental interaction detection)
Huang et al., J Biol Chem 2000*
-
IRef Biogrid Interaction:
BIRC3
—
CASP3
(physical association, affinity chromatography technology)
Rajalingam et al., PLoS Pathog 2006*
-
IRef Biogrid Interaction:
BIRC3
—
CASP3
(direct interaction, pull down)
Roy et al., EMBO J 1997
-
IRef Hprd Interaction:
BIRC3
—
CASP3
(in vitro)
Roy et al., EMBO J 1997
-
IRef Innatedb Interaction:
BIRC3
—
CASP3
(unknown, -)
Rajalingam et al., PLoS Pathog 2006*
-
IRef Ophid Interaction:
BIRC3
—
CASP3
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Partheniou et al., Biochem Biophys Res Commun 2001
(Leukemia) :
In contrast, there was a
caspase dependent cleavage of XIAP, but not
c-IAP1 , during treatment with TNFalpha for 7 days
Mica et al., J Am Coll Surg 2004
(Sepsis) :
Endotoxin reduces CD95 induced neutrophil apoptosis by
cIAP-2 mediated
caspase-3 degradation
Dürkop et al., J Mol Med (Berl) 2006
:
cIAP2 is highly expressed in Hodgkin-Reed-Sternberg cells and
inhibits apoptosis by interfering with constitutively
active caspase-3
Levkovitch-Verbin et al., Invest Ophthalmol Vis Sci 2006
(Disease Models, Animal...) :
Proapoptotic genes from the p-53 pathway ( Ei24 and Gadd45a ), Cdk2 and the prosurvival gene
IAP-1 ( a
caspase inhibitor ) were simultaneously and significantly upregulated early after ONT, returning to baseline at 2 weeks
Igaki et al., Biochem Biophys Res Commun 2007
:
DmHtrA2 specifically cleaves Drosophila
inhibitor-of-apoptosis protein 1 ( DIAP1 ), a cellular
caspase inhibitor , and induces cell death both in vitro and in vivo as potent as other fly cell death proteins
Das et al., Cancer 2007
(Glioblastoma) :
Other events in apoptosis included overexpression of Bax, down-regulation of Bcl-2 and some
BIRC proteins, mitochondrial release of cytochrome c and Smac into the cytosol, and
activation of calpain,
caspase-9 , and caspase-3
Das et al., Brain Res 2008
(Brain Neoplasms...) :
Besides, apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : Bcl-2 ratio, mitochondrial release of cytochrome c and Smac, downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing (
BIRC ) molecules, an increase in intracellular free [Ca2+ ], and
activation of calpain and
caspase-3
Karmakar et al., Neuroscience 2009
(Body Weight...) :
Combination of 4-HPR and GST increased Bax : Bcl-2 ratio, mitochondrial release of Smac, downregulation of baculovirus inhibitor-of-apoptosis repeat containing (
BIRC ) proteins including BIRC-2 and BIRC-3, and activation of
caspase-3 and apoptosis
inducing factor ( AIF )