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AKT3 — GNRH1

Text-mined interactions from Literome

Rose et al., J Biol Chem 2004 (MAP Kinase Signaling System) : The LHRH induced inhibition of Akt stimulated by IGF-1 was completely blocked by Safingol, a protein kinase C (PKC) alpha-specific inhibitor, and by a dominant negative form of PKCalpha ... Finally, we showed that the inhibitory effect of LHRH on IGF-1 induced PKCalpha mediated Akt activation was associated with a marked reduction in Bad phosphorylation and a substantial decrease in the ability of IGF-1 to rescue alphaT3 cells from apoptosis induced by serum starvation
Mutiara et al., Mol Cell Endocrinol 2008 : Using the well differentiated, clonal gonadotroph cell line, LbetaT2, we examined ( 1 ) whether Akt/PKB was activated by gonadotropin releasing hormone (GnRH) ; ( 2 ) the contribution of PI3-kinase-Akt/PKB pathway in each of gonadotropin subunit gene expression ; ( 3 ) crosstalk between extracellular signal regulated kinase ( ERK ) and Akt/PKB pathways ... Akt/PKB activation by GnRH and IGF-1 was completely eliminated in the presence of the PI3-kinase inhibitor, LY 294002, but not in the presence of an Akt/PKB inhibitor
Ling Poon et al., Endocrinology 2011 (Ovarian Neoplasms) : In our studies of OVCAR-3 and CaOV-3 ovarian cancer cell lines, GnRH-II treatment induced phosphorylation of Akt and glycogen synthase kinase ( GSK ) 3ß, as well as ß-catenin accumulation in the nucleus, and the latter was reduced by small interfering RNA ( siRNA ) -mediated depletion of the GnRH receptor