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CDKN1A — VDR
Text-mined interactions from Literome
Tokumoto et al., Nephrol Dial Transplant 2003
(Hyperparathyroidism, Secondary) :
In the myelomonocytic cell line, active vitamin D ( 3 ) is known to activate the transcription of both
p21 and p27, cyclin dependent kinase inhibitors ( CDKIs ), regulating the transition from the G ( 1 ) to the S phase of the cell cycle, in a
VDR dependent manner
Wu et al., Cancer Lett 2007
(MAP Kinase Signaling System) :
1alpha,25-Dihydroxyvitamin D ( 3 ) antiproliferative actions involve
vitamin D receptor mediated activation of MAPK pathways and
AP-1/p21 ( waf1 ) upregulation in human osteosarcoma
Xie et al., Med Oncol 2010
(Breast Neoplasms) :
To confirm whether
VDR contributes to
p21 upregulation, we used two constructs that express luciferase
Thorne et al., Nucleic Acids Res 2011
(Prostatic Neoplasms) :
In parallel,
VDR binding to the MCM7 gene induced H3K9ac enrichment associated with rapid mRNA up-regulation to generate miR-106b and consequently
regulate p21 ( ( waf1/cip1 ) ) expression