Gene interactions and pathways from curated databases and text-mining

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CDKN1A — VDR

Text-mined interactions from Literome

Tokumoto et al., Nephrol Dial Transplant 2003 (Hyperparathyroidism, Secondary) : In the myelomonocytic cell line, active vitamin D ( 3 ) is known to activate the transcription of both p21 and p27, cyclin dependent kinase inhibitors ( CDKIs ), regulating the transition from the G ( 1 ) to the S phase of the cell cycle, in a VDR dependent manner
Wu et al., Cancer Lett 2007 (MAP Kinase Signaling System) : 1alpha,25-Dihydroxyvitamin D ( 3 ) antiproliferative actions involve vitamin D receptor mediated activation of MAPK pathways and AP-1/p21 ( waf1 ) upregulation in human osteosarcoma
Xie et al., Med Oncol 2010 (Breast Neoplasms) : To confirm whether VDR contributes to p21 upregulation, we used two constructs that express luciferase
Thorne et al., Nucleic Acids Res 2011 (Prostatic Neoplasms) : In parallel, VDR binding to the MCM7 gene induced H3K9ac enrichment associated with rapid mRNA up-regulation to generate miR-106b and consequently regulate p21 ( ( waf1/cip1 ) ) expression