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IRF6 — PTX3

Text-mined interactions from Literome

Goodman et al., J Leukoc Biol 2000 : Furthermore, cycloheximide greatly reduced LPS induced TSG-14 mRNA up-regulation in macrophages but not in 3T3 cells ... Finally, interferon-gamma ( IFN-gamma ; but not IFN-alpha/beta ) inhibited LPS induced TSG-14 expression in macrophages and not in 3T3 fibroblasts ... The antioxidant pyrrolidine dithiocarbamate inhibited LPS induced nuclear factor-kappaB (NF-kappaB) activation and TSG-14 expression in macrophages ... Inhibition of LPS induced TSG-14 mRNA expression by IFN-gamma in macrophages was also observed in the presence of cycloheximide and in cells from STAT1 null mice, suggesting that IFN-gamma inhibits TSG-14 expression through an unconventional mechanism
Norata et al., J Intern Med 2005 (Carotid Stenosis) : Furthermore, we investigated whether monocyte from D299G to T399I subjects present a defective response to CD40, interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, cyclo-oxygenase (COX)-2 and PTX3 expression induced by lipopolysaccharide (LPS)
Han et al., J Immunol 2005 : Using human lung cell lines and primary epithelial cells, we found that PTX3 expression was significantly up-regulated by TNF-alpha in a time- and dose dependent manner, but not by LPS
Doni et al., J Leukoc Biol 2006 : It was unexpected that lipopolysaccharide (LPS) stimulated PTX3 production was enhanced by IL-10 and inhibited by IL-4 and interferon-gamma (IFN-gamma)
Fan et al., Frontiers in bioscience : a journal and virtual library 2006 (Gram-Negative Bacterial Infections...) : The induction of these cytokines was significantly ( p < 0.05 ) suppressed by PTx. Glucan treatment alone had no effect on cytokine production but suppressed ( P < 0.05 ) LPS and SA induced cytokines. PTx further augmented ( p > 0.05 ) the inhibitory effect of glucan on the LPS and SA induced cytokine expression
Okutani et al., Am J Physiol Lung Cell Mol Physiol 2007 (Acute Disease...) : To determine the effects of HS, LPS , or injurious ventilation ( 25 ml/kg ) alone on PTX3 expression, another group of rats was studied
Parhar et al., Mediators Inflamm 1993 : In the present study the effects of PTX on lipopolysaccharide (LPS) and cytokine induced T-cell and macrophage ( PhiM ) activation, and on natural killer ( NK ) cell and lymphokine activated killer ( LAK ) cell mediated cytotoxicity were examined
Maina et al., J Leukoc Biol 2009 (Inflammation) : Anti-inflammatory cytokines, such as IL-4, dampened LPS induced TSG-6 and PTX3 expression
May et al., Biol Reprod 2010 : We studied the association between the number of children given birth by women during their lifetime and ex vivo, lipopolysaccharide (LPS) induced PTX3 production ( n = 362 ) ... We found that ex vivo LPS induced PTX3 production was associated with fertility ( P = 0.040 )
Alles et al., Blood 1994 : Inhibition of transcription by actinomycin D blocked induction of PTX3 in monocytes and nuclear run-on analysis showed that LPS induces the expression of the PTX3 gene at the transcriptional level in isolated monocytes
Schratzberger et al., Immunopharmacology 1999 : In the present study, we investigated the effects of the anti-inflammatory drug pentoxifylline ( PTX ) on activation of endothelial cells for enhanced adhesion and transmigration of neutrophils by lipopolysaccharide (LPS) , tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1) and granulocyte colony stimulating factor ( G-CSF ) ... Upon stimulation with TNF or LPS , HUVEC produced IL-8 and PTX affected this process in opposing fashions, with inhibition of the effects of TNF and augmentation of those of LPS