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MLYCD — PRKAG2

Text-mined interactions from Literome

Saha et al., J Biol Chem 2000 : The results strongly suggest that activation of AMPK during muscle contraction leads to phosphorylation of MCD and an increase in its activity
Habinowski et al., Arch Biochem Biophys 2001 : We have investigated the potential regulation of MCD by AMPK in exercising skeletal muscle, in an islet cell line, and in vitro
Hopkins et al., Biochem Soc Trans 2003 (Myocardial Ischemia...) : In addition, it is suggested that AMPK also phosphorylates and activates MCD , promoting degradation of malonyl-CoA levels
Sambandam et al., Eur J Biochem 2004 : We therefore overexpressed MCD ( Ad.MCD ) and constitutively active AMPK ( Ad.CA-AMPK ) in H9c2 cells, using an adenoviral gene delivery approach in order to examine if MCD is regulated by AMPK ... Co-expressing AMPK with MCD further augmented MCD expression and activity in Ad.MCD + Ad.CA-AMPK cells compared with the Ad.MCD + Ad.GFP control ... Interestingly, in the mitochondrial fractions, MCD activity significantly increased in Ad.MCD + Ad.CA-AMPK cells when compared with Ad.MCD + Ad.GFP cells ... This differential regulation of MCD expression and activity in the mitochondria by AMPK may potentially regulate malonyl-CoA levels at sites nearby CPT-I on the mitochondria