Gene interactions and pathways from curated databases and text-mining

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CTNNB1 — STK11

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CTNNB1 → STK11 (decreases, STK11 Activity)
    Evidence: other studies have indicated that Lkb1 downregulates the b-catenin pathway through either activation of GSK3—a negative regulator of b-catenin—or through diverting MARK2/ Par1a from its capacity to activate the pathway (Spicer et al., 2003; Lin-Marq et al., 2005).

Text-mined interactions from Literome

Ossipova et al., Nat Cell Biol 2003 : These studies show that LKB1/XEEK1 is required for Wnt-beta-catenin signalling in frogs and mammals and provides novel insights into its role in vertebrate developmental patterning and carcinogenesis
Ma et al., Oncol Rep 2010 (Adenocarcinoma...) : These findings suggest that Wnt signaling may be activated in a subset of PJSs, and activation of the Wnt/beta-catenin signaling in PJS polyps may be caused by LKB1 expression