◀ Back to CNTN2

APC — CNTN2

Text-mined interactions from Literome

Liu et al., Mol Cell Biol 2003 (Aneuploidy) : Our results support the notion that Tax aberrantly targets and activates APC ( Cdc20p ), leading to unscheduled degradation of Pds1p/securin and Clb2p/cyclin B1, a delay or failure in mitotic entry and progression, and faulty chromosome transmission
Liu et al., Proc Natl Acad Sci U S A 2005 : Consistent with the notion that Tax activates APC ( Cdc20 ) directly, Tax is found to coimmunoprecipitate with Cdc20 and Cdc27/APC3 ... Unscheduled activation of APC ( Cdc20 ) by Tax provides an explanation for the mitotic abnormalities in HTLV-I infected cells and is likely to play an important role in the development of adult T cell leukemia
Kuo et al., EMBO J 2006 (Cell Transformation, Viral) : Here, we show that APC activation by Tax induces rapid senescence (tax-IRS) independently of p53 and pRB ... These results indicate that APC activation by Tax causes inactivation of SCF ( Skp2 ) and stabilization of p21 ( CIP1/WAF1 ) and p27 ( KIP1 )