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BMP2 — CRK

Text-mined interactions from Literome

Kimura et al., J Biol Chem 2000 : We demonstrate that BMP2 induces activation of TGF-beta activated kinase ( TAK1 ) and subsequent phosphorylation of p38 stress activated protein kinase ... Interestingly, this ectopic expression of Smad6 blocks BMP2 induced TAK1 activation and p38 phosphorylation
Hallahan et al., Nat Med 2003 (Brain Neoplasms...) : BMP-2 also induced p38 mitogen activated protein kinase ( MAPK ), which is necessary for BMP-2- and retinoid induced apoptosis
Lemonnier et al., J Biol Chem 2004 : In this study, we investigated the molecular mechanism by which BMP-2 activates JNK and p38 in MC3T3-E1 osteoblastic cells ... To further document an implication of PKD in activation of JNK and p38 induced by BMP-2 , we constructed MC3T3-E1 cells stably expressing PKD antisense oligonucleotide ( AS-PKD )
Nöth et al., Exp Cell Res 2003 : These findings suggest that BMP-2 must activate p38 in order to mediate osteogenic differentiation and maturation
Guicheux et al., J Bone Miner Res 2003 (MAP Kinase Signaling System) : We report that BMP-2 can activate JNK and p38 in osteoblastic cells and provide evidences that these MAP kinases have distinct roles in regulating alkaline phosphatase and osteocalcin expression
Scherberich et al., Oncogene 2005 (Breast Neoplasms...) : Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro
Celil et al., J Biol Chem 2005 : IGF-I mediated Osx expression required all three MAPK components ( Erk, p38, and JNK ), whereas BMP-2 required p38 and JNK signaling
Inagaki et al., Endocrinology 2009 : Bone morphogenetic protein (BMP)-2 and BMP-4 also enhanced FSH induced p38 phosphorylation, which was augmented by oocyte action ... Thus, BMP-2 and BMP-4 differentially regulate steroidogenesis by stimulating FSH induced p38 and suppressing cAMP
Chiou et al., Life Sci 2011 : Noggin also abrogated 8-PK evoked phosphorylations of Smad1/5/8 and p38, suggesting that BMP-2 signaling is required for p38 activation in 8-PK treated cells
Gamell et al., PloS one 2011 : We report here that BMP-2 regulation of cell migration and actin cytoskeleton remodelling are dependent on p38 activity
Park et al., Anticancer Drugs 2013 (Bone Neoplasms...) : Whereas BMP-2 mainly activated ERK1/2, BMP-9 phosphorylated p38 within 1 h. pBMP-2 did not activate either the Smad or ERK/p38, whereas pBMP-9, like BMP-9, induced both Smad1/5/8 and p38 phosphorylation
Suto et al., Arch Oral Biol 2013 (MAP Kinase Signaling System) : Nano-HA induced BMP-2 expression was dependent on the p38 MAP kinase pathway because increases in BMP-2 expression were inhibited by treatment with SB203580, a p38 inhibitor, and phosphorylation of p38 was detected by Western blotting
Guang et al., Int J Biochem Cell Biol 2013 : Mechanistically, impaired BMP2- or Dex-osteoinduction in BMSCs of elderly mice was mediated by inhibited phosphorylation of intracellular R-Smads and Erk1/2 or Erk1/2 and p38 proteins, and decreased Runx2 and Osx expression ( osteogenesis `` master '' regulators ) were also detected