Baratelli et al., J Immunol 2004
:
These findings indicate that PGE2 dependent enhancement of TIMP-1 production causes reduced migration of DC through ECM Yokose et al., J Invest Dermatol 2012
:
Overexpression of TIMP-1 resulted in significant inhibition of UVB induced ECM degradation, as well as suppression of decreased skin elasticity and roughness, whereas the NAB mediated inhibition of TIMP-1 had opposite effects
Shankland et al., J Am Soc Nephrol 1996
(Diabetes Mellitus, Experimental) :
These studies suggest that an early increase in TIMP-1 , a protein that decreases extracellular metalloproteinase activity, may contribute to a decrease in ECM protein degradation in the diabetic glomerulus