Gene interactions and pathways from curated databases and text-mining

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IGF1 — LHCGR

Text-mined interactions from Literome

Hirakawa et al., Endocrinology 1999 : A role of insulin-like growth factor I in luteinizing hormone receptor expression in granulosa cells
Lagaly et al., Mol Cell Endocrinol 2008 : Adiponectin decreased ( P < 0.05 ) insulin induced progesterone and androstenedione production as well as attenuated IGF-I induced LHR , CYP11A1, and CYP17A1 gene expression in theca cells. In contrast, adiponectin decreased ( P < 0.05 ) LHR mRNA abundance in granulosa cells but did not affect steroidogenic enzyme gene expression in granulosa cells. Adiponectin had no effect ( P > 0.10 ) on proliferation of large-follicle theca cells
Lou et al., Sci China C Life Sci 2000 : IGF-I stimulated LHR expression in CL. PGF ( 2alpha ) inhibited expression of IGF-IR and LHR
Luo et al., Sci China C Life Sci 2000 : Meanwhile, it was observed that EGF promoted IGF-I mRNA expression, and in preovulatory follicles, IGF-I stimulated LHR mRNA expression
Kanzaki et al., Mol Cell Endocrinol 1994 : Basic fibroblast growth factor induces luteinizing hormone receptor expression in the presence of insulin-like growth factor-I in ovarian granulosa cells
Zhang et al., Biol Reprod 1998 (Leydig Cell Tumor) : In the present study, we assessed the effect of IGF-I on LH receptor (LHR) gene expression in an immortalized murine Leydig tumor cell line ( BLT-1 )