◀ Back to FOS
CEBPA — FOS
Pathways - manually collected, often from reviews:
-
BioCarta keratinocyte differentiation:
c/EBP-alpha (CEBPA)
→
SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
c/EBP-alpha (CEBPA)
→
AP-1 complex (FOS-JUN)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
SP1
→
SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
HOXA7
→
SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA)
(modification, inhibits)
-
BioCarta keratinocyte differentiation:
SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA)
→
AP-1 complex (FOS-JUN)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
SP1/c-FOS/c-JUN/ETS/c/EBP-alpha complex (SP1-FOS-JUN-ETS2_ETS1-CEBPA)
→
ETS (ETS2/ETS1)
(modification, collaborate)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Liu et al., Blood 2003
:
C/EBPalpha-ER strongly
inhibited endogenous
AP-1 DNA binding
Gagliardi et al., J Biol Chem 2003
:
C/EBP inhibition enhanced the expression of the three major components of AP-1 in cycling CEF, namely c-Jun, JunD, and Fra-2, and
stimulated AP-1 activity
Calella et al., Neural development 2007
:
C/EBPalpha and NeuroD co-operatively
activated the
Fos promoter in transfection assays
Hong et al., J Leukoc Biol 2011
:
C/EBPa :
AP-1 heterodimers bound either site preferentially in a gel-shift assay, C/EBPa : c-Fos ER fusion proteins induced endogenous Fosb mRNA but not in the
presence of CHX,
C/EBP and AP-1 proteins bound the endogenous Fosb promoter, mutation of the -56 cis element reduced reporter activity fivefold, and endogenous FosB protein was expressed preferentially during monopoiesis versus granulopoiesis