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PTGS2 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
PTGS2
—
TP53
(coimmunoprecipitation)
Corcoran et al., Oncogene 2005*
-
IRef Biogrid Interaction:
PTGS2
—
TP53
(direct interaction, pull down)
Choi et al., Biochim Biophys Acta 2009*
-
IRef Biogrid Interaction:
PTGS2
—
TP53
(association, biochemical)
Choi et al., Biochim Biophys Acta 2009*
-
IRef Biogrid Interaction:
PTGS2
—
TP53
(physical association, affinity chromatography technology)
King et al., Oncogene 2001*
-
IRef Hprd Interaction:
TP53
—
PTGS2
(in vivo)
King et al., Oncogene 2001*
-
IRef Ophid Interaction:
PTGS2
—
TP53
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
PTGS2
—
TP53
(aggregation, confirmational text mining)
King et al., Oncogene 2001*
Text-mined interactions from Literome
Zahner et al., J Biol Chem 2002
:
These data suggest that
COX-2 inhibits mesangial cell proliferation by a novel mechanism that is independent of prostaglandin synthesis, but
involves p53 , p21 ( cip-1 ), and p27 ( kip-1 )
Han et al., EMBO J 2002
:
We also found that p53 induced Cox-2 expression results from p53 mediated activation of the Ras/Raf/MAPK cascade, as demonstrated by suppression of
Cox-2 induction in
response to
p53 by dominant negative Ras or Raf1 mutants ... Together, these results demonstrate that
Cox-2 is
induced by
p53 mediated activation of the Ras/Raf/ERK cascade, counteracting p53 mediated apoptosis
Shigemasa et al., Int J Oncol 2003
(Adenocarcinoma...) :
COX-2 overexpression in ovarian cancer cells might partly be
caused by dysfunctional
p53
Han et al., Mech Ageing Dev 2004
(Arthritis, Rheumatoid...) :
The selective
COX-2 inhibitor, NS-398, can
inhibit the senescence associated increases of COX-2, PGE ( 2 ),
p53 and MMP-1 expression, and the senescence associated decreases of PCNA, TIMP-1 and procollagen expression
Lee et al., Head Neck 2004
(Carcinoma, Squamous Cell...) :
Effects of
p53 or p27 overexpression on
cyclooxygenase-2 gene expression in head and neck squamous cell carcinoma cell lines ... The
effects of
p53 or p27 gene transfer on
COX-2 expression by adenoviral vector and the combined effects of p53 or p27 gene transfer and COX-2 inhibitor exposure on the proliferation of cancer cells were investigated in head and neck squamous cell carcinoma ( HNSCC ) cell lines ... Overexpression of
p53 markedly downregulated the transcription of COX-2, but the overexpression of p27 did not
affect COX-2 levels in HNSCC cell lines
Kim et al., Toxicological sciences : an official journal of the Society of Toxicology 2005
:
In addition, 2,2',4,6,6'-PeCB stimulated COX-2 induction was reduced by the specific MAPK kinase ( MEK ) inhibitor, PD98059, and in p53-deficient cells, implying that
COX-2 induction
requires the activation of ERK1/2 MAPK and
p53
Liu et al., J Biol Chem 2005
(Anoxia...) :
To elucidate the
effects of
COX-2 on
p53 in response to hypoxia, we transfected the COX-2 gene into the p53 positive, COX-2 negative MDA-PCa-2b human prostate cancer cell line ... Overexpression of
COX-2 abrogated hypoxia induced p53 phosphorylation and
promoted the binding of
p53 to Mdm2 protein in hypoxic cells ... Finally, forced expression of
COX-2 suppressed both basal and hypoxia induced
p53 transcriptional activity, and this effect was mimicked by the addition of PGE2 to wild-type cells ... These results demonstrated a
role for
COX-2 in the suppression of hypoxia induced
p53 activity via both direct effects and indirect modulation of Mdm2 activity
Corcoran et al., Oncogene 2005
(Breast Neoplasms...) :
Here we report that the
tumor suppressor p53 upregulates
COX-2 expression and that COX-2 can in turn inhibit p53 dependent transcription ... Expression of exogenous
COX-2 in p53 wild-type cells does not
affect the cytoplasmic or nuclear levels of
p53 , suggesting that COX-2 may not affect p53 turnover or subcellular localization ... Thus,
p53 upregulates
COX-2 and COX-2 in turn appears to negatively affect p53 activity via mechanisms that could involve physical interactions between COX-2 and p53 ... Based on our results, we propose that
p53 dependent upregulation and activation of
COX-2 appear to be yet another novel mechanism by which p53 could abate its own growth-inhibitory and apoptotic effects
Choi et al., Biochem Biophys Res Commun 2005
:
COX-2 regulates
p53 activity and inhibits DNA damage induced apoptosis ... We have previously shown that p53 induces cyclooxygenase-2 (COX-2) expression and
COX-2 inhibits
p53- or genotoxic stress induced apoptosis
Lee et al., Int J Gynecol Cancer 2006
(Adenocarcinoma...) :
p53 may be
responsible for the regulation of
COX-2 expression
Ogino et al., Neoplasia (New York, N.Y.) 2006
(Colorectal Neoplasms) :
Cyclooxygenase-2 (COX-2) overexpression and mutations of
p53 ( a known
COX-2 regulator ) are inversely associated with microsatellite instability-high ( MSI-H ) and CpG island methylator phenotype ( CIMP ) characterized by extensive promoter methylation, is associated with MSI-H
Atula et al., Oncol Rep 2006
(Carcinoma, Squamous Cell...) :
COX-2 expression is
suppressed by the wild-type but not by the mutant tumour suppressor gene
TP53
Lim et al., Yonsei Med J 2007
(Adenocarcinoma...) :
Existing evidence suggests that
COX-2 expression is normally
suppressed by wild-type
p53 but not mutant p53, suggesting that loss of p53 function may result in the induction of COX-2 expression
Lin et al., J Cell Biochem 2008
(Head and Neck Neoplasms...) :
Resveratrol induced nuclear
COX-2 accumulation was
dependent upon ERK1/2 activation, but not
p53 activation ...
Activation of
p53 and p53 dependent apoptosis were blocked by the
COX-2 inhibitor, NS398, and by transfection of cells with COX-2-siRNA ... Resveratrol-inducible nuclear accumulation of
COX-2 is
essential for
p53 activation and p53 dependent apoptosis in these cancer cells
Hermanova et al., Eur J Gastroenterol Hepatol 2008
(Adenocarcinoma...) :
The
p53 dependent upregulation of
COX-2 was proposed to be another mechanism by which p53 could abate its own growth-inhibitory and apoptotic effects
Zdanov et al., Biogerontology 2009
:
p53 and ATF-2 partly
mediate the overexpression of
COX-2 in H ( 2 ) O ( 2 ) -induced premature senescence of human fibroblasts
Duarte et al., Cancer Lett 2009
(Carcinoma, Non-Small-Cell Lung...) :
Role of
p53 in the induction of
cyclooxygenase-2 by cisplatin or paclitaxel in non-small cell lung cancer cell lines ... Therefore, we suggest that induction of
COX-2 by cisplatin in NSCLC cell lines is
dependent on
p53
Choi et al., Biochim Biophys Acta 2009
:
The p53 interacting region was critical for
COX-2 mediated inhibition of p53 DNA binding and transcriptional activity as well as
p53- and genotoxic stress induced apoptosis ... In addition, an active site mutant of
COX-2 ( S516Q ) as well as wild-type COX-2 potently
inhibited p53 transcriptional activity and genotoxic stress induced apoptosis
Gesser et al., Inflamm Res 2011
(Psoriasis) :
The expression of
p-p53 ( S15 ) was
induced simultaneously with the inhibition of
Cox-2
Park et al., Mol Carcinog 2012
(Colonic Neoplasms...) :
HFD feeding increased tumor tissue levels of Ki67, cyclin A, cyclin D1, CDK2, Bcl-xL, and Bcl-2 ; reduced
p53 levels and TUNEL positive apoptotic cells ;
increased the levels of CD45, CD68, CD31, VEGF, P-VEGF receptor-2, iNOS, and
COX-2 as well as hemoglobin content ; and increased the levels of HIF-1a, P-STAT3-Y705, P-STAT3-S727, P-I?B-a, P-p65, p65, P-c-Jun, P-Akt, P-ERK1/2, P-p38, and P-SAPK/JNK
Katkoori et al., Biotech Histochem 2013
(Prostatic Neoplasms) :
Reduced COX-2 expression was found with decreased
p53 in LNCaP and PC-3 cells that were exposed to = 20 µM of celecoxib for 72 h, but
COX-2 expression was
increased in DU145 cells
Dagouassat et al., Am J Respir Crit Care Med 2013
(Pulmonary Disease, Chronic Obstructive) :
PGE2 acts either in a paracrine or autocrine fashion by a pathway involving EP2 and EP4 prostaglandin receptors,
cyclooxygenase-2 dependent reactive oxygen species production and signaling, and consecutive
p53 activation