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NFKB1 — SERPINE1

Text-mined interactions from Literome

Dechend et al., Circulation 1999 (Arteriosclerosis) : Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-kappaB and induces tissue factor and PAI-1 expression : a potential link to accelerated arteriosclerosis
Maeda et al., J Biol Chem 2001 (Stomach Neoplasms) : In conclusion, H. pylori induced NF-kappaB activation in epithelial cells is dependent on cag PAI and contact but does not involve CD14 and IRAK, whereas in macrophage/monocytic cells it is independent of cag PAI or contact but involves CD14 and TLR4
Philpott et al., Cell Microbiol 2002 (Disease Models, Animal...) : Six isolates were shown to harbour a complete cag PAI and to induce NF- kappa B activation and IL-8 secretion in AGS cells
Hamaguchi et al., J Pharmacol Exp Ther 2003 : A protein tyrosine kinase inhibitor, genistein, completely inhibited TNF-alpha induced PAI-1 secretion, whereas an inhibitor of extracellular signal regulated kinase ( ERK ) kinase, 2'-amino-3'-methoxyflavone ( PD98059 ), and a nuclear factor-kappaB (NF-kappaB) inhibitor, emodin, partly inhibited TNF-alpha induced PAI-1 secretion
Li et al., Kidney Int 2005 (Anoxia) : Inhibition of nuclear factor-kappaB (NF-kappaB) caused a moderate decrease in PAI-1 production under hypoxia
Swiatkowska et al., FEBS J 2005 : We show that activation of PAI-1 gene by TNFalpha and reactive oxygen species is mediated by interaction of NF-kappaB with the cis acting element located in the -675 4G/5G insertion/deletion in the PAI-1 promoter
Iwasaki et al., Atherosclerosis 2008 (Hyperglycemia) : NF-kappaB activity determined using the luciferase reporter gene assay was significantly enhanced by high glucose, and pretreatment with Y-27632 inhibited high glucose induced PAI-1 expression at the basal level ... An inhibitor of NF-kappaB action, namely parthenolide ( 0.1 microM ), BAY 11-7082 ( 5 microM ) and SN50 ( 1 microM ), significantly blocked high glucose mediated PAI-1 expression to a level with low glucose ( 5.7 mM ) ... These data suggested that high glucose induced PAI-1 expression in endothelial cells is mediated by NF-kappaB activation through the Rho/Rho-kinase pathway
Vaziri et al., J Pharmacol Exp Ther 2007 (Disease Models, Animal...) : The untreated group exhibited hypertension, deterioration of renal function and structure, reduced or unchanged plasma renin activity, aldosterone concentration, marked up-regulations of AT1r ( 250 % ), Ang II-expressing cell count ( > 20-fold ), NAD ( P ) H oxidase subunits ( gp91(phox,) p22(phox), and P47 ( phox ) ; 20-40 % ), COX-2 ( 250 % ), 12-lipooxygenase ( 100 % ), MCP-1 ( 400 % ), and PAI-1 ( > 20-fold ), activation of NFkappaB , and interstitial infiltrations of T cells and macrophages in the remnant kidneys
Laumen et al., Atherosclerosis 2008 : In conclusion our data suggest that rosuvastatin inhibits PAI-1 expression and release from human adipocytes via a MEKK-1 dependent but not a NFkappaB dependent mechanism
Collins-Underwood et al., Free Radic Biol Med 2008 : We report that irradiating rat brain microvascular endothelial cells in vitro leads to increased ( i ) intracellular ROS generation, ( ii ) activation of the transcription factor NFkappaB , ( iii ) expression of ICAM-1 and PAI-1 , and ( iv ) expression of Nox4, p22(phox), and p47(phox) ... Pharmacologic and genetic inhibition of NADPH oxidase blocked the radiation mediated upregulation of intracellular ROS, activation of NFkappaB , and upregulation of ICAM-1 and PAI-1
Takeshima et al., BMC microbiology 2009 (Helicobacter Infections) : The inflammatory response in Helicobacter pylori infected gastric tissue is mediated by cag pathogenicity island (PAI) dependent activation of nuclear factor-kappaB (NF-kappaB)