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ILK — PARVB

Pathways - manually collected, often from reviews:

• KEGG Focal adhesion: PARVA/PARVB/PARVG → ILK (protein-protein, binding/association)
• NCI Pathway Database Integrin-linked kinase signaling: ILK/PINCH1/beta parvin complex (ILK-LIMS1-PARVB) → alpha-actinin (ACTN1) (modification, collaborate) Fukuda et al., J Biol Chem 2003, Yamaji et al., J Cell Biol 2004
  Evidence: physical interaction
• NCI Pathway Database Integrin-linked kinase signaling: ILK/PINCH1/beta parvin complex (ILK-LIMS1-PARVB) → ILK/PINCH1/beta parvin/alpha-actinin complex (ILK-LIMS1-PARVB-ACTN1) (modification, collaborate)
  Fukuda et al., J Biol Chem 2003, Yamaji et al., J Cell Biol 2004
  Evidence: physical interaction
• NCI Pathway Database Integrin-linked kinase signaling: alpha-actinin (ACTN1) → ILK/PINCH1/beta parvin/alpha-actinin complex (ILK-LIMS1-PARVB-ACTN1) (modification, collaborate)
  Fukuda et al., J Biol Chem 2003, Yamaji et al., J Cell Biol 2004
  Evidence: physical interaction
• NCI Pathway Database Integrin-linked kinase signaling: PINCH1 (LIMS1) → ILK/PINCH1/beta parvin complex (ILK-LIMS1-PARVB) (modification, collaborate)
  Yamaji et al., J Cell Biol 2004
  Evidence: physical interaction
• NCI Pathway Database Integrin-linked kinase signaling: ILK/PINCH1/beta parvin complex (ILK-LIMS1-PARVB) → beta parvin (PARVB) (modification, collaborate) Yamaji et al., J Cell Biol 2004
  Evidence: physical interaction
• NCI Pathway Database Integrin-linked kinase signaling: ILK/PINCH1/beta parvin complex (ILK-LIMS1-PARVB) → ILK (ILK) (modification, collaborate) Yamaji et al., J Cell Biol 2004
  Evidence: physical interaction
• NCI Pathway Database Integrin-linked kinase signaling: beta parvin (PARVB) → ILK (ILK) (modification, collaborate) Yamaji et al., J Cell Biol 2004
  Evidence: physical interaction
• NCI Pathway Database Integrin-linked kinase signaling: beta parvin (PARVB) → ILK (ILK) (modification, collaborate) Yamaji et al., J Cell Biol 2001*, Yamaji et al., J Cell Biol 2004
  Evidence: physical interaction
• NCI Pathway Database Integrin-linked kinase signaling: beta parvin (PARVB) → ILK/beta parvin complex (ILK-PARVB) (modification, collaborate)
  Yamaji et al., J Cell Biol 2001*, Yamaji et al., J Cell Biol 2004
  Evidence: physical interaction
• NCI Pathway Database Integrin-linked kinase signaling: ILK (ILK) → ILK/beta parvin complex (ILK-PARVB) (modification, collaborate)
  Yamaji et al., J Cell Biol 2001*, Yamaji et al., J Cell Biol 2004
  Evidence: physical interaction
• WikiPathways Focal Adhesion: ILK → ZYX/VASP/VCL/PARVB (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: ILK — PARVB (coimmunoprecipitation) Yamaji et al., Biochem Biophys Res Commun 2002*
• IRef Biogrid Interaction: ILK — PARVB (physical association, affinity chromatography technology) Varjosalo et al., Nat Methods 2013
• IRef Biogrid Interaction: ILK — PARVB (physical association, affinity chromatography technology) Ewing et al., Molecular systems biology 2007
• MIPS CORUM ILK-PARVB-ARHGEF6 complex: ILK-PARVB-ARHGEF6 complex complex (ARHGEF6-ILK-PARVB) Filipenko et al., Oncogene 2005*
• IRef Corum Interaction: Complex of ILK-ARHGEF6-PARVB (association, anti tag coimmunoprecipitation) Filipenko et al., Oncogene 2005*
• IRef Hprd Interaction: ILK — PARVB (in vitro) Yamaji et al., J Cell Biol 2001*, Mongroo et al., Oncogene 2004*
• IRef Hprd Interaction: ILK — PARVB (two hybrid) Yamaji et al., J Cell Biol 2001*, Mongroo et al., Oncogene 2004*
• IRef Hprd Interaction: ILK — PARVB (in vivo) Yamaji et al., J Cell Biol 2001*, Mongroo et al., Oncogene 2004*
• IRef Intact Interaction: Complex of 58 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: ILK — PARVB (physical association, anti bait coimmunoprecipitation) Ewing et al., Molecular systems biology 2007
• IRef Ophid Interaction: ILK — PARVB (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Yamaji et al., J Cell Biol 2001 : These results provide evidence suggesting that affixin is involved in integrin-ILK signaling required for the establishment of cell-substrate adhesion
Mongroo et al., Oncogene 2004 (Breast Neoplasms) : Beta-parvin inhibits integrin linked kinase signaling and is downregulated in breast cancer ... Conversely, ILK protein and kinase activity levels were elevated in these tumors, suggesting that downregulation of ParvB stimulates ILK signaling ... ParvB inhibited ILK kinase activity, anchorage independent cell growth and in vitro matrigel invasion by MDA-MB-231 cells ... These results indicated that ParvB inhibits ILK signaling downstream of receptor tyrosine kinases
Sepulveda et al., Cell Mol Life Sci 2006 (Disease) : In contrast to PARVA, PARVB inhibits ILK activity and reverses some of its oncogenic effects in cancer cells