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EGF — TGFB1

Text-mined interactions from Literome

Cupp et al., Biol Reprod 1999 : Interestingly, TGFbeta1 inhibited epidermal growth factor (EGF) , and 10 % calf serum stimulated P0 testis cell growth but not FSH stimulated growth
Voci et al., Eur J Endocrinol 1999 : The effects of transforming growth factor-alpha ( TGF-alpha ), through EGF receptors to induce a mitogenic response, and transforming growth factor-beta1 ( TGF-beta1 ), produced by non-parenchymal liver cells and able to inhibit hepatocyte proliferation in vivo and in culture, have been studied in cultured adult rat hepatocytes
Wenner et al., Braz J Med Biol Res 1999 (Cell Transformation, Neoplastic) : Perturbation of EGF induced MAP kinase activation by TGF-beta 1 ... TGF-beta 1 delayed EGF- or PDGF induced cyclin D1 expression and blocked the induction of active p42/p44MAPK
Asher et al., J Neurosci 2000 (Brain Injuries) : The amount detected was increased by transforming growth factor beta and to a greater extent by epidermal growth factor and was decreased by platelet derived growth factor and, to a lesser extent, by interferon gamma
Loukinova et al., Int J Cancer 2001 (Carcinoma, Squamous Cell...) : TGF-beta1 suppressed constitutive as well as IL-1alpha and EGF-inducible Gro 1 production in both Pam 212 and LY-2 cells
Hardin et al., J Cell Biochem 2002 (Cell Transformation, Neoplastic) : SAMDC mRNA expression was increased in response to epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) stimulation but was unaffected by transforming growth factor beta(1) ( TGF-beta(1) ) and platelet derived growth factor ( PDGF )
Wang et al., Ophthalmic Genet 2002 : The TGFBI gene transcript in this human corneal epithelial cell line is upregulated by growth factor TGF-beta( 1) , but is not affected by growth factor EGF
Yamasaki et al., J Invest Dermatol 2003 : The epidermal growth factor dependent induction of p3TP-lux luciferase activity was disrupted by transfection of the dominant negative form of transforming growth factor beta type I receptor adenovirus vector ( AxdnALK5 ), which suggests that epidermal growth factor induced transforming growth factor beta acts in an autocrine manner in keratinocytes
Hongo et al., Exp Eye Res 1992 : The results showed that TGF-beta 1 induced the high affinity receptors in the keratocytes, although TGF-beta 1 did not influence EGF receptors in the epithelial and endothelial cells
Zarzyńska et al., J Dairy Res 2005 : Exogenous TGF-beta1, IGF-I, EGF and GH inhibited FBS-deficiency stimulated TGF-beta1 expression
Murillo et al., Oncogene 2005 : We show that TGF-beta1 activates the epidermal growth factor receptor (EGFR) and phosphorylates c-Src ... Inhibitors of TACE considerably attenuated Akt activation, which suggests that TGF-beta1 activates EGF signalling in hepatocytes by promoting shedding of EGF-like ligands
Song et al., J Biol Chem 2006 (Prostatic Neoplasms) : Novel permissive role of epidermal growth factor in transforming growth factor beta ( TGF-beta ) signaling and growth suppression
Yang et al., Biol Reprod 2006 : EGF attenuated TGFB1 stimulated phosphorylation of SMAD3, TGFB1 induced activation of MAPK14 and PKC, and TGFB1 suppression of CCND2 degradation
Bister et al., Mod Pathol 2007 (Adenocarcinoma...) : TIMP-4 expression was induced by TGFbeta1 in PANC-1 cells and by EGF in BxPC-3 cells
Uttamsingh et al., Oncogene 2008 (Cell Transformation, Neoplastic) : TGF-beta1 augmented EGF mediated signaling of mitogen activated protein kinase ( MAPK ) and AKT by enhancing and prolonging the activation of the former and prolonging the activation of the latter
He et al., Invest Ophthalmol Vis Sci 2008 : Rabbit corneal keratocytes ( RCKs ) were treated with EGF, TGF-beta1, or EGF plus TGF-beta1 in the presence or absence of inhibitors of EGF-receptor (EGF-R) , neutralizing concentrations of EGF antibody and of signaling kinases for 2 days to 1 week ... TGF-beta1 in the presence of EGF also increased cell migration, which is inhibited by blocking EGF-R activation
Danielpour et al., J Cell Physiol 1991 : We show that epidermal growth factor (EGF) induces secretion of TGF-beta 1 and not TGF-beta 2, whereas retinoic acid ( RA ) induces secretion of TGF-beta 2 and not TGF-beta 1 in NRK-49F normal rat kidney fibroblasts and A549 human lung carcinoma cells ... The interactive effects of EGF , RA, and Dex on the production of TGF-beta 1 and TGF-beta 2, which were studied on NRK-49F cells, demonstrate that EGF blocks the induction of TGF-beta 2 mRNA and peptide by RA, while Dex inhibits the induction of TGF-beta 1 mRNA and peptide by EGF
Schlumberger et al., Arterioscler Thromb 1991 : We found that EGF enhanced TGF-beta 1-induced protein production in collagen lattices but not in monolayer cultures
Liang et al., Arch Oral Biol 1990 : Thus epidermal growth factor stimulates DNA synthesis and both transforming growth factor-beta and epidermal growth factor inhibit ALPase activity of clonal rat pulp cells, suggesting that both factors may act as regulators of biological function, including cell differentiation, in pulp cells
Matrisian et al., Mol Cell Biol 1986 : However, transforming growth factor beta could block the EGF induction of transin RNA
Nugent et al., Cancer Res 1989 (Cell Transformation, Neoplastic) : Growth stimulation, altered regulation of epidermal growth factor receptors, and autocrine transformation of spontaneously transformed normal rat kidney cells by transforming growth factor beta
Kerr et al., J Biol Chem 1988 : Transforming growth factor beta 1 and cAMP inhibit transcription of epidermal growth factor- and oncogene induced transin RNA
Russell et al., Proc Natl Acad Sci U S A 1988 (Cicatrix...) : Whereas transforming growth factor beta reduced growth stimulation by epidermal growth factor in cells from normal adult skin or scars, it enhanced the activity of epidermal growth factor in cells from keloids
Shiota et al., Biochem Int 1986 : Distinct effects of transforming growth factor-beta on EGF receptors and EGF induced DNA synthesis in primary cultured rat hepatocytes
Brinckerhoff et al., Arthritis Rheum 1983 : Morphologic and mitogenic responses of rabbit synovial fibroblasts to transforming growth factor beta require transforming growth factor alpha or epidermal growth factor
Hayward et al., In Vitro Cell Dev Biol Anim 1995 (Aneuploidy) : In serum-free culture in plastic dishes epidermal growth factor (EGF) , transforming growth factor (TGF)-alpha, fibroblast growth factor (FGF) 1 ( aFGF ), and FGF 7 ( KGF ) induced increased proliferation in these cells whereas FGF 2 ( bFGF ), TGF-beta 1 , and TGF-beta 2 inhibited proliferative activity
Zanardi et al., Int J Cancer 1994 (Fibrocystic Breast Disease) : Our results also suggest that EGF accumulation in this type of cysts might be regulated by TGF-beta 1
Otani et al., J Urol 1994 (Carcinoma, Renal Cell...) : In accordance with the invasiveness, EGF enhanced the activity of type IV collagenolysis in SRCC-1P, and TGF-beta 1 suppressed it in SRCC-1M
Newman et al., Cancer Metastasis Rev 1993 (Cell Transformation, Neoplastic...) : TGF-beta 1 also regulates cell growth by controlling the response to epidermal growth factor (EGF) and other growth factors, in ways that can either decrease or increase their growth promoting effects
Sakata et al., Int J Cancer 1993 (Endometrial Neoplasms) : These findings suggest that TGF-beta 1 may be a potential autocrine growth factor in a human endometrial cancer cell line IK-90 and that this autocrine mechanism may be affected by EGF
Schluns et al., Int Immunol 1995 : In vitro, epidermal growth factor (EGF) increases transcript levels of TGF-beta 1 , TGF-beta 3 and T beta RII, suggesting that EGF may modulate TGF-beta responses in TEC ; however, TGF-beta 2 and T beta RI transcript levels were not affected
Woodworth et al., Cell Growth Differ 1996 (Carcinoma, Squamous Cell) : TGF-beta 1 increased expression of RNAs encoding the EGF-R and amphiregulin, and also increased numbers of cell-surface EGF-Rs without altering their affinity
Yokozeki et al., Exp Cell Res 1997 (Cicatrix...) : Neither epidermal growth factor nor basic fibroblast growth factor had any effect on either alpha-SM actin expression or TGF-beta 1 mRNA expression
Gărtner et al., Thyroid 1997 : The stimulatory effect of EGF and TGF alpha on TGF beta 1 expression might be related to extracellular matrix modulation during proliferation
Franch et al., Am J Physiol 1997 (Hypertrophy) : One mechanism contributing to hypertrophy is that EGF induces activation of the cell cycle and increases protein synthesis, whereas TGF-beta 1 prevents cell division, thereby converting hyperplasia to hypertrophy
Itoh et al., Endocrinology 1998 : Epidermal growth factor (EGF) stimulated TGFbeta1 mRNA expression in stromal cells ( 6-fold increase ), whereas keratinocyte growth factor stimulated TGFbeta2 mRNA in epithelial cells
Lacroix et al., Cancer Lett 1998 (Breast Neoplasms) : The production of Il-11 was increased by transforming growth factor-beta1 in a dose dependent manner with a rapid ( 2 h ) and transient ( 24 h ) mRNA induction, but not by epidermal growth factor , insulin-like growth factor-I and -II, basic fibroblast growth factor, platelet derived growth factor or parathyroid hormone
Thannickal et al., Biochem Biophys Res Commun 1998 : TGF-beta1 had no effect on epidermal growth factor (EGF) or platelet derived growth factor ( PDGF ) -beta receptor expression and the mitogenic responses mediated by specific ligands for these receptors were not increased