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MBP — NOX3
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Shenoy et al., J Immunol 2003
:
We conclude that MBP stimulates a Src kinase dependent activation of class I ( A ) PI3K and, in turn, activation of PKCzeta in neutrophils, which contributes to the activation of
NADPH oxidase and the resultant O ( 2 ) ( - ) production in
response to
MBP stimulation
Zor et al., Biochem J 1993
:
Treatment of macrophages with vanadate plus TPA led to
activation of protein kinase C ( PKC ) and
NADPH oxidase ( O2- generation in intact cells ), massive cellular protein tyrosine phosphorylation, suppression of protein tyrosine phosphatase (PTP) activity and a sustained activation of protein tyrosine kinase ( PTK ) and
myelin basic protein kinase activity ( the latter three enzyme activities were assessed in cell lysates )