◀ Back to SYK

BLNK — SYK

Pathways - manually collected, often from reviews:

• KEGG Osteoclast differentiation: SYK → BLNK/LCP2 (protein-protein, activation)
• KEGG B cell receptor signaling pathway: SYK → BLNK (protein-protein, phosphorylation)
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK) → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, collaborate)
  Adachi et al., J Biol Chem 2001
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK) → CD72/SHP1 complex (CD72-PTPN6) (modification, collaborate)
  Adachi et al., J Biol Chem 2001
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK) → SHP1 (PTPN6) (modification, collaborate) Adachi et al., J Biol Chem 2001
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → CD72/SHP1 complex (CD72-PTPN6) (modification, collaborate)
  Adachi et al., J Biol Chem 2001
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → SHP1 (PTPN6) (modification, collaborate) Adachi et al., J Biol Chem 2001
• NCI Pathway Database BCR signaling pathway: SAB (SH3BP5) → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, inhibits)
  Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
• NCI Pathway Database BCR signaling pathway: SAB (SH3BP5) → B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A) (modification, inhibits)
  Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → PLCgamma2 (PLCG2) (modification, collaborate) Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A) (modification, collaborate)
  Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → Btk (BTK) (modification, collaborate) Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
• NCI Pathway Database BCR signaling pathway: PLCgamma2 (PLCG2) → B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A) (modification, collaborate)
  Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A) → Btk (BTK) (modification, collaborate) Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A) → IBtk (IBTK) (modification, collaborate) Yamadori et al., Proc Natl Acad Sci U S A 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Liu et al., Nat Immunol 2001, Rodriguez et al., Biochem J 2003
• NCI Pathway Database BCR signaling pathway: BLNK (BLNK) → B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A) (modification, collaborate)
  Kabak et al., Mol Cell Biol 2002
  Evidence: physical interaction
• NCI Pathway Database BCR signaling pathway: BLNK (BLNK) → B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A) (modification, collaborate)
  Kabak et al., Mol Cell Biol 2002
  Evidence: physical interaction
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A) → B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A) (modification, collaborate)
  Kabak et al., Mol Cell Biol 2002
  Evidence: physical interaction
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK) → CD72 (CD72) (modification, collaborate) Fusaki et al., Eur J Immunol 2000
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK) → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, collaborate)
  Fusaki et al., Eur J Immunol 2000
• NCI Pathway Database BCR signaling pathway: CD72 (CD72) → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, collaborate)
  Fusaki et al., Eur J Immunol 2000
• NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT) → Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK) (modification, collaborate)
  Shan et al., J Biol Chem 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Rawlings et al., Science 1996, August et al., Proc Natl Acad Sci U S A 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT) → BTK-ITK (ITK/BTK) (modification, collaborate) Shan et al., J Biol Chem 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Rawlings et al., Science 1996, August et al., Proc Natl Acad Sci U S A 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK) → BTK-ITK (ITK/BTK) (modification, collaborate) Shan et al., J Biol Chem 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Rawlings et al., Science 1996, August et al., Proc Natl Acad Sci U S A 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Class I PI3K signaling events: None → Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) (modification, collaborate)
  Rodriguez et al., Biochem J 2003
  Evidence: mutant phenotype, other species
• NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) (modification, activates) Rodriguez et al., Biochem J 2003
  Evidence: mutant phenotype, other species
• NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) → None (modification, activates) Rodriguez et al., Biochem J 2003
  Evidence: mutant phenotype, other species
• NCI Pathway Database Class I PI3K signaling events: PLC-gamma family (PLCG1/PLCG2) → Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) (modification, collaborate)
  Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Class I PI3K signaling events: PLC-gamma family (PLCG1/PLCG2) → Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK) (modification, collaborate)
  Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) → Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK) (modification, collaborate)
  Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database BCR signaling pathway: CD19 (CD19) → B-cell antigen/BCR complex/LYN/SYK/BLNK complex (LYN-SYK-BLNK-CD79B-CD79A) (modification, activates)
  O'Rourke et al., Immunity 1998
  Evidence: assay, physical interaction
• NCI Pathway Database BCR signaling pathway: SHIP (INPP5D) → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, inhibits)
  
• NCI Pathway Database BCR signaling pathway: None → B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, collaborate)
  
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) (modification, activates)
• NCI Pathway Database BCR signaling pathway: B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK) → None (modification, activates)
• Reactome Reaction: SYK → BLNK (reaction) Watanabe et al., Biochem Biophys Res Commun 2000, Engels et al., Eur J Immunol 2001, Kabak et al., Mol Cell Biol 2002, Chiu et al., EMBO J 2002, Oellerich et al., Mol Cell Proteomics 2009, Oellerich et al., EMBO J 2011, Fu et al., J Biol Chem 1997, Fu et al., Immunity 1998, Wienands et al., J Exp Med 1998
• Reactome Reaction: SYK → BLNK (indirect_complex) Watanabe et al., Biochem Biophys Res Commun 2000, Engels et al., Eur J Immunol 2001, Kabak et al., Mol Cell Biol 2002, Chiu et al., EMBO J 2002, Oellerich et al., Mol Cell Proteomics 2009, Oellerich et al., EMBO J 2011, Fu et al., J Biol Chem 1997, Fu et al., Immunity 1998, Wienands et al., J Exp Med 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SYK — BLNK (physical association, affinity chromatography technology) Oellerich et al., EMBO J 2011
• IRef Biogrid Interaction: SYK — BLNK (physical association, affinity chromatography technology) Janda et al., Blood 2011*
• IRef Hprd Interaction: SYK — BLNK (in vivo) Guo et al., Immunity 2000*
• IRef Intact Interaction: SYK — BLNK (physical association, pull down) Kulathu et al., EMBO J 2008*
• IRef Ophid Interaction: SYK — BLNK (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Abudula et al., J Biol Chem 2007 (Calcium Signaling) : Second, we dissected these processes by expressing SLP-65 in SLP-76-deficient T cells and found that a kinase independent adaptor function of Syk is required to link phosphorylated SLP-65 to Ca ( 2+ ) mobilization
Chen et al., Blood 2008 (Lymphoma, Large B-Cell, Diffuse) : In R406-sensitive DLBCL cell lines, R406 specifically inhibited both tonic- and ligand induced BCR signaling ( autophosphorylation of SYK525/526 and SYK dependent phosphorylation of the B-cell linker protein [ BLNK ] )