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IL4 — ITGB1
Text-mined interactions from Literome
Colantonio et al., Blood 1999
:
Upregulation of
integrin alpha6/beta1 and chemokine receptor CCR1 by
interleukin-12 promotes the migration of human type 1 helper T cells
Suwaki et al., Int Immunopharmacol 2001
(Asthma...) :
PAF or
IL-4 did not
enhance VLA-4 expression on eosinophils, and there was no significant effect of suplatast on VLA-4 expression in allergic patients
Ishii et al., J Oral Pathol Med 1990
:
TNF-alpha,
interleukin-4 (IL-4), and transforming growth factor beta ( TGF-beta )
suppressed CD29 expression, while other cytokines, including interleukin-3 and granulocyte-macrophage colony stimulating factor, were without effect
Sasaki et al., J Immunol 2008
(Neoplasms) :
Our recent studies have suggested that
VLA-4 expression on CD8+ T cells is negatively
controlled by
IL-4 and serves as a functionally distinguishing variable for why Type-1, but not Type-2, CD8+ T cells are able to traffic into tumors ... In this study, using in vitro culture of murine CD8+ T cells under Type-1 and Type-2 cytokine conditions, we show that
IL-4 mediated down-regulation of
VLA-4 expression is completely abrogated in Stat6-deficient CD8+ T cells
Sasaki et al., Eur J Immunol 2008
(Melanoma, Experimental) :
IL-4 inhibits
VLA-4 expression on Tc1 cells resulting in poor tumor infiltration and reduced therapy benefit ... Notably, the inhibitory
effects of
IL-4 on Tc1 expression of
VLA-4 could be blocked by the presence of IL-12, but not IFN-gamma
Paganin et al., Cytokine 1994
:
The levels of inhibition with resting vs IL-1 activated EC, as well as antibody blocking experiments, suggested that IL-4 exerts an inhibitory influence predominantly on the beta 2-integrin ( CD18 ) -dependent adhesion pathway ; nevertheless
IL-4 did not
affect the expression of CD18/CD11a and
VLA-4 on the NK cell surface, as assessed by flow cytometry