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IL4 — SEA
Text-mined interactions from Literome
King et al., Parasite Immunol 2001
(Schistosomiasis mansoni) :
By contrast, CD4+ splenocytes produced comparatively little cytokine release by endogenous antigen, whereas exogenous
SEA strongly
induced IL-4 , IL-5, IL-10 and IFN-gamma production and lymphocyte proliferation that correlated poorly with the dynamics of granulomatous inflammation
Hattori et al., Clin Exp Allergy 2002
(Disease Models, Animal...) :
Moreover, it partially inhibited the production of
IL-4 by nasal lymphocytes in
response to
SEA
Koyanagi et al., Int Immunol 2004
:
In contrast,
SEA induced
IL-4 production was high in neonatal thymic CD4 SP T cell blasts, and low in adult splenic and thymic CD4 SP T cell blasts
Shen et al., Parasite Immunol 2003
(Schistosomiasis japonica) :
S. japonicum soluble worm antigen ( SWAP ) and
soluble egg antigen (SEA) stimulated
IL-4 , IL-5 and IFN-gamma production in whole-blood cultures were measured by ELISA
Ramos et al., Mem Inst Oswaldo Cruz 2006
(Disease Models, Animal...) :
Interleukins,
IL-4 and IL-10
responses to
soluble egg antigens (SEA) 90 days after infection, were determined
Shen et al., Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 2007
(Schistosomiasis japonica) :
The level of
IL-4 in spleen cells from group A in
response to ConA and
SEA ( 79.7 and 50.7 pg/ml, respectively ) was lower than that of group D ( 125.2 and 70.5 pg/ml, respectively ) ( P < 0.01 )
Ghadimi et al., Immunobiology 2008
(Hypersensitivity) :
Lactobacilli and bifidobacteria reduced
SEA stimulated
IL-4 and IL-5 production more effectively in PBMCs from healthy subjects than from allergic patients
Ferreira et al., Mem Inst Oswaldo Cruz 2012
(Chronic Disease...) :
We demonstrate that stimulation with
SEA induced prominent lymphocyte proliferation and high levels of tumour necrosis factor (TNF)-a,
interleukin (IL)-4 and IL-10 secretion in both OST and non infected individuals ( NI )
da Silva et al., TheScientificWorldJournal 2012
(Schistosomiasis mansoni) :
Histopathological analysis of liver tissue showed changes in morphological aspects of the hepatic parenchyma with decrease exudative-productive hepatic granuloma stages, although we found no significant differences in IFN-?,
IL-4 , IL-10, or NO production in
response to the specific antigen
SEA
Boghdadi et al., Parasitol Res 2013
(Liver Cirrhosis...) :
Levels of interferon-? ( IFN-? ),
interleukin 4 (IL-4), IL-10, and IL-13 were measured by ELISA in the supernatants of cultured peripheral blood mononuclear cells ( PBMC ) in
response to schistosoma egg
soluble antigen (SEA) in the presence and absence of R848
König et al., Int Arch Allergy Immunol 1995
(Dermatitis, Atopic) :
In contrast to normal donors T cells from donors with AD predominantly express mRNA for
IL-4 , IL-5, and only diminished levels for IFN-gamma and IL-12 upon
stimulation with SEB and
SEA
Falcone et al., Eur J Immunol 1996
:
Moreover, resensitization of stripped basophils with stripping supernatants or human serum restored
SEA induced
IL-4 production
Grogan et al., Eur J Immunol 1996
(Schistosomiasis haematobia) :
Interleukin (IL)-4 production in
response to both AWA and
soluble egg antigen (SEA) increased markedly after treatment ( p < 0.001 ), but IL-5 remained unchanged
Hobeika et al., Biochem Biophys Res Commun 1996
:
A synthetic peptide of this region, SEA ( 121-149 ), blocks
SEA binding to class II MHC molecules and
induces interleukin-1 and tumor necrosis factor production in monocytes
Wahl et al., Kidney Int 1997
(Granuloma...) :
In mice,
soluble egg antigens (SEA) induce
interleukin 4 synthesis, promoting a dominant T helper type 2 lymphocyte accumulation with the release of additional cytokines ( IL-5, IL-10 ), which not only suppress Th1 lymphocyte subset cytokines, but mediate the characteristic pathophysiology