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GSK3B — TGFB1

Text-mined interactions from Literome

Yoshino et al., Biochem Biophys Res Commun 2007 (Fibrosis) : TGF-beta1 increased the phosphorylated form of GSK-3beta in HKC-8 cells, and inhibition of GSK-3beta by the selective inhibitors lithium and TDZD-8 caused Snail1 protein to accumulate
Caraci et al., Pharmacol Res 2008 : TGF-beta1 also increased the expression of the Ser-9 phosphorylated inactive form of glycogen synthase kinase-3beta ( GSK-3beta ), an effect that was largely attenuated by PD98059
Clifford et al., J Biol Chem 2008 : Novel regulation of vascular endothelial growth factor-A ( VEGF-A ) by transforming growth factor (beta)1 : requirement for Smads, ( beta)-CATENIN, AND GSK3(beta)
Li et al., J Am Soc Nephrol 2009 (Disease Models, Animal...) : Pharmacologic inhibition of ILK with small-molecule inhibitor QLT-0267 abolished TGF-beta1 induced phosphorylation of Akt and glycogen synthase kinase-3beta , suppressed cyclin D1 expression, and largely restored the expression of E-cadherin and zonula occludens 1
Deng et al., Am J Physiol Lung Cell Mol Physiol 2010 (Hypertension...) : Unlike epidermal growth factor, BMP-4, TGF-beta1 , 5-HT, and ET-1 each increased smooth muscle cell size, contractile protein expression, fractional cell shortening, and GSK-3beta phosphorylation ... Expression of a non-phosphorylatable GSK-3beta mutant blocked BMP-4-, TGF-beta1- , 5-HT-, and ET-1 induced cell size enlargement, suggesting that GSK-3beta phosphorylation is required and sufficient for cellular hypertrophy
Hua et al., Eur J Pharmacol 2010 : Glycogen synthase kinase-3beta negatively regulates TGF-beta1 and Angiotensin II-mediated cellular activity through interaction with Smad3 ... These results uncovered a novel mechanism for the GSK3beta negative regulation of TGF-beta1/Smad3 and Angiotensin II/Smad3 mediated transcription and apoptosis by the identification of a crosstalk between GSK3beta and Smad3 signal pathway