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APAF1 — E2F1

Pathways - manually collected, often from reviews:

• NCI Pathway Database E2F transcription factor network: E2F1/DP complex (E2F1-TFDP2_TFDP1) → APAF-1 (APAF1) (transcription, activates) Moroni et al., Nat Cell Biol 2001*, Logan et al., Oncogene 2004*, Logan et al., Oncogene 2005*
  Evidence: mutant phenotype, reporter gene

Text-mined interactions from Literome

Moroni et al., Nat Cell Biol 2001 : Apaf-1 is a transcriptional target for E2F and p53 ... Here we show that E2F1 directly regulates the expression of Apaf-1 , the gene for apoptosis protease activating factor 1
Wright et al., J Cell Biol 2007 : Surprisingly, we find that E2F1 is sufficient to induce Apaf-1 expression in developing but not mature neurons ... Rather, Apaf-1 up-regulation in mature neurons requires both chromatin derepression and E2F1 transcriptional activity ... This differential capacity of E2F1 to induce Apaf-1 transcription is because of the association of the Apaf-1 promoter with active chromatin in developing neurons and repressed chromatin in mature neurons
Johnson et al., Proc Natl Acad Sci U S A 2007 (Astrocytoma...) : ChIP assays reveal that E2F1 binds the Apaf-1 promoter specifically in tumor tissue, suggesting that E2F1 contributes to the expression of Apaf-1 in brain tumors